Metabolic mapping of rat forebrain and midbrain during delay and trace eyeblink conditioning

Bethany PLAKKE; John H FREEMAN; Amy POREMBA

doi:10.1016/j.nlm.2009.04.001

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Metabolic mapping of rat forebrain and midbrain during delay and trace eyeblink conditioning

Journal article

Peer reviewed

Metabolic mapping of rat forebrain and midbrain during delay and trace eyeblink conditioning

Bethany PLAKKE, John H FREEMAN and Amy POREMBA

Neurobiology of learning and memory, Vol.92(3), pp.335-344

2009

DOI: 10.1016/j.nlm.2009.04.001

PMCID: PMC3630995

PMID: 19376256

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https://www.ncbi.nlm.nih.gov/pmc/articles/3630995View

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Abstract

While the essential neural circuitry for delay eyeblink conditioning has been largely identified, much of the neural circuitry for trace conditioning has yet to be determined. The major difference between delay and trace conditioning is a time gap between the presentation of the conditioned stimulus (CS) and the unconditioned stimulus (US) during trace conditioning. It is this time gap, which accounts for the additional memory component and may require extra neural structures, including hippocampus and prefrontal cortex. A metabolic marker of energy use, radioactively labeled glucose analog, was used to compare differences in glucose analog uptake between delay, trace, and unpaired experimental groups (rats, Long-Evans), to identify possible new areas of involvement within forebrain and midbrain. Here, we identify increased 2-DG uptake for the delay group compared to the unpaired group in various areas including: the medial geniculate nuclei (MGN), the amygdala, cingulate cortex, auditory cortex, medial dorsal thalamus, and frontal cortices. For the trace group, compared to the unpaired group, there was an increase in 2-DG uptake for the medial orbital frontal cortex and the medial MGN. The trace group also exhibited more increases lateralized to the right hemisphere, opposite to the side of US delivery, in various areas including: CA1, subiculum, presubiculum, perirhinal cortex, ventral and dorsal MGN, and the basolateral and central amygdala. While some of these areas have been identified as important for delay or trace conditioning, some new structures have been identified such as the orbital frontal cortex for both delay and trace groups.

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Behavioral psychophysiology

Psychology. Psychoanalysis. Psychiatry

Psychology. Psychophysiology

Details

Title: Subtitle: Metabolic mapping of rat forebrain and midbrain during delay and trace eyeblink conditioning
Creators: Bethany PLAKKE - University of Iowa, Department of Psychology, E11 SSH, Iowa City, IA 52242, United States
John H FREEMAN - University of Iowa, Department of Psychology, E11 SSH, Iowa City, IA 52242, United States
Amy POREMBA - University of Iowa, Department of Psychology, E11 SSH, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Neurobiology of learning and memory, Vol.92(3), pp.335-344
DOI: 10.1016/j.nlm.2009.04.001
PMID: 19376256
PMCID: PMC3630995
NLM abbreviation: Neurobiol Learn Mem
ISSN: 1074-7427
eISSN: 1095-9564
Publisher: Elsevier; Amsterdam
Language: English
Date published: 2009
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065860702771

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