Journal article
Metabolic perturbations in the diabetic heart: Mechanisms and molecular targets
Drug discovery today. Disease mechanisms, Vol.2(1), pp.115-122
2005
DOI: 10.1016/j.ddmec.2005.04.002
Abstract
Diabetes is associated with altered myocardial substrate utilization, specifically increased fatty acid (FA) utilization and decreased glucose utilization. This switch in substrate utilization is associated with decreased cardiac efficiency and decreased energetic reserves, and can increase the risk of heart failure. Potential mechanisms include increased delivery of FAs to the heart, upregulation of FA utilization pathways via activation of transcription factors such as PPAR-α, myocardial insulin resistance and mitochondrial dysfunction. This review will summarize our current understanding of the pathophysiology of metabolic disturbances in the diabetic heart and will discuss potential therapeutic targets.
Michael Sack – National Institutes of Health, MD, USA
Details
- Title: Subtitle
- Metabolic perturbations in the diabetic heart: Mechanisms and molecular targets
- Creators
- E. Dale Abel - Program in Human Molecular Biology and Genetics and Division of Endocrinology Metabolism and Diabetes, University of Utah School of Medicine, 15 North 2030 East, Building #533, Room 3410B, Salt Lake City, UT 84112, USA
- Resource Type
- Journal article
- Publication Details
- Drug discovery today. Disease mechanisms, Vol.2(1), pp.115-122
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.ddmec.2005.04.002
- ISSN
- 1740-6765
- eISSN
- 1740-6765
- Language
- English
- Date published
- 2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Biochemistry and Molecular Biology; Internal Medicine; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism
- Record Identifier
- 9984024525402771
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