Metabolic rate regulation by the renin-angiotensin system: brain vs. body

Justin L Grobe; Kamal Rahmouni; Xuebo Liu; Curt D Sigmund

doi:10.1007/s00424-012-1096-9

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Metabolic rate regulation by the renin-angiotensin system: brain vs. body

Journal article

Open access

Peer reviewed

Metabolic rate regulation by the renin-angiotensin system: brain vs. body

Justin L Grobe, Kamal Rahmouni, Xuebo Liu and Curt D Sigmund

Pflügers Archiv, Vol.465(1), pp.167-175

01/2013

DOI: 10.1007/s00424-012-1096-9

PMCID: PMC3569511

PMID: 22491893

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https://www.ncbi.nlm.nih.gov/pmc/articles/3569511View

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Abstract

Substantial evidence supports a role for the renin-angiotensin system (RAS) in the regulation of metabolic function, but an apparent paradox exists where genetic or pharmacological inhibition of the RAS occasionally has similar physiological effects as chronic angiotensin infusion. Similarly, while RAS targeting in animal models has robust metabolic consequences, effects in humans are more subtle. Here, we review the data supporting a role for the RAS in metabolic rate regulation and propose a model where the local brain RAS works in opposition to the peripheral RAS, thus helping to explain the paradoxically similar effects of RAS supplementation and inhibition. Selectively modulating the peripheral RAS or brain RAS may thus provide a more effective treatment paradigm for obesity and obesity-related disorders.

Brain - metabolism

Animals

Energy Metabolism

Humans

Homeostasis

Renin-Angiotensin System - genetics

Renin-Angiotensin System - physiology

Brain - physiology

Details

Title: Subtitle: Metabolic rate regulation by the renin-angiotensin system: brain vs. body
Creators: Justin L Grobe - Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 3181 MERF, 375 Newton Rd., Iowa City, IA 52242, USA
Kamal Rahmouni
Xuebo Liu
Curt D Sigmund
Resource Type: Journal article
Publication Details: Pflügers Archiv, Vol.465(1), pp.167-175
DOI: 10.1007/s00424-012-1096-9
PMID: 22491893
PMCID: PMC3569511
NLM abbreviation: Pflugers Arch
ISSN: 0031-6768
eISSN: 1432-2013
Publisher: Germany
Grant note: HL048058 / NHLBI NIH HHS R00 HL098276 / NHLBI NIH HHS HL014388 / NHLBI NIH HHS HL061446 / NHLBI NIH HHS HL084207 / NHLBI NIH HHS R01 HL061446 / NHLBI NIH HHS P01 HL014388 / NHLBI NIH HHS HL098276 / NHLBI NIH HHS R01 HL048058 / NHLBI NIH HHS P01 HL084207 / NHLBI NIH HHS R37 HL048058 / NHLBI NIH HHS K99 HL098276 / NHLBI NIH HHS
Language: English
Date published: 01/2013
Academic Unit: Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040488002771

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