Metabolic signatures associated with Western and Prudent dietary patterns in women

Paulette D Chandler; Raji Balasubramanian; Nina Paynter; Franco Giulianini; Teresa Fung; Lesley F Tinker; Linda Snetselaar; Simin Liu; Charles Eaton; Deirdre K Tobias; Fred K Tabung; JoAnn E Manson; Edward L Giovannucci; Clary Clish; Kathryn M Rexrode

doi:10.1093/ajcn/nqaa131

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Metabolic signatures associated with Western and Prudent dietary patterns in women

Journal article

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Metabolic signatures associated with Western and Prudent dietary patterns in women

Paulette D Chandler, Raji Balasubramanian, Nina Paynter, Franco Giulianini, Teresa Fung, Lesley F Tinker, Linda Snetselaar, Simin Liu, Charles Eaton, Deirdre K Tobias, …

The American journal of clinical nutrition, Vol.112(2), pp.268-283

08/01/2020

DOI: 10.1093/ajcn/nqaa131

PMCID: PMC7398790

PMID: 32520313

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Abstract

The Western dietary pattern (WD) is positively associated with risk of coronary artery disease (CAD) and cancer, whereas the Prudent dietary pattern (PD) may be protective. Foods may influence metabolite concentrations as well as oxidative stress and lipid dysregulation, biological mechanisms associated with CAD and cancer. The aim was to assess the association of 2 derived dietary pattern scores with serum metabolites and identify metabolic pathways associated with the metabolites. We evaluated the cross-sectional association between each dietary pattern (WD, PD) and metabolites in 2199 Women's Health Initiative (WHI) participants. With FFQ and factor analysis, we determined 2 dietary patterns consistent with WD and PD. Metabolites were measured with LC-tandem MS. Metabolite discovery among 904 WHI Observational Study (WHI-OS) participants was replicated among 1295 WHI Hormone Therapy Trial (WHI-HT) participants. We analyzed each of 495 metabolites with each dietary score (WD, PD) in linear regression models. The PD included higher vegetables and fruit intake compared with the WD with higher saturated fat and meat intake. Independent of energy intake, BMI, physical activity, and other confounding variables, 45 overlapping metabolites were identified (WHI-OS) and replicated (WHI-HT) with an opposite direction of associations for the WD compared with the PD [false discovery rate (FDR) P < 0.05]. In metabolite set enrichment analyses, phosphatidylethanolamine (PE) plasmalogens were positively enriched for association with WD [normalized enrichment score (NES) = 2.01, P = 0.001, FDR P = 0.005], and cholesteryl esters (NES = -1.77, P = 0.005, FDR P = 0.02), and phosphatidylcholines (NES = -1.72, P = 0.01, P = 0.03) were negatively enriched for WD. PE plasmalogens were positively correlated with saturated fat and red meat. Phosphatidylcholines and cholesteryl esters were positively correlated with fatty fish. Distinct metabolite signatures associated with Western and Prudent dietary patterns highlight the positive association of mitochondrial oxidative stress and lipid dysregulation with a WD and the inverse association with a PD.

Aged

Coronary Disease - metabolism

Cross-Sectional Studies

Diet, Healthy

Diet, Western - adverse effects

Fats - metabolism

Feeding Behavior

Female

Humans

Middle Aged

Mitochondria - metabolism

Neoplasms - metabolism

Oxidative Stress

Vegetables - metabolism

Details

Title: Subtitle: Metabolic signatures associated with Western and Prudent dietary patterns in women
Creators: Paulette D Chandler - Harvard Medical School, Boston, MA, USA
Raji Balasubramanian - Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA
Nina Paynter - Harvard Medical School, Boston, MA, USA
Franco Giulianini - Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Teresa Fung - Department of Nutrition, Simmons University, Boston, MA, USA
Lesley F Tinker - Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Linda Snetselaar - University of Iowa College of Public Health, Iowa City, IA, USA
Simin Liu - Brown University School of Public Health and Alpert School of Medicine, Providence, RI, USA
Charles Eaton - Brown University School of Public Health and Alpert School of Medicine, Providence, RI, USA
Deirdre K Tobias - Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA
Fred K Tabung - Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA
JoAnn E Manson - Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA
Edward L Giovannucci - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Clary Clish - Broad Institute of MIT and Harvard, Cambridge, MA, USA
Kathryn M Rexrode - Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Resource Type: Journal article
Publication Details: The American journal of clinical nutrition, Vol.112(2), pp.268-283
DOI: 10.1093/ajcn/nqaa131
PMID: 32520313
PMCID: PMC7398790
ISSN: 0002-9165
eISSN: 1938-3207
Grant note: R00 CA207736 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P30 DK040561 / NIDDK NIH HHS
Language: English
Date published: 08/01/2020
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215045202771

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