Metabolism and metabolites of polychlorinated biphenyls

Fabian A Grimm; Dingfei Hu; Izabela Kania-Korwel; Hans-Joachim Lehmler; Gabriele Ludewig; Keri C Hornbuckle; Michael W Duffel; Åke Bergman; Larry W Robertson

doi:10.3109/10408444.2014.999365

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Metabolism and metabolites of polychlorinated biphenyls

Journal article

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Metabolism and metabolites of polychlorinated biphenyls

Fabian A Grimm, Dingfei Hu, Izabela Kania-Korwel, Hans-Joachim Lehmler, Gabriele Ludewig, Keri C Hornbuckle, Michael W Duffel, Åke Bergman and Larry W Robertson

Critical Reviews in Toxicology, Vol.45(3), pp.245-272

03/16/2015

DOI: 10.3109/10408444.2014.999365

PMCID: PMC4383295

PMID: 25629923

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Abstract

The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable metabolites are formed in the processes of biotransformation in biota in general, and in humans in particular. The aim of this document is to provide an overview of PCB metabolism, and to identify the metabolites of concern and their occurrence. Emphasis is given to mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood. Potential intracellular targets and health risks are also discussed.

PCB methyl sulfones

hydroxylated PCBs

PCB sulfates

human exposure

reactive intermediates

polychlorobiphenylols

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Title: Subtitle: Metabolism and metabolites of polychlorinated biphenyls
Creators: Fabian A Grimm - Department of Pharmaceutical Sciences & Experimental Therapeutics, University of Iowa
Dingfei Hu - Department of Civil and Environmental Engineering, University of Iowa
Izabela Kania-Korwel - Department of Occupational & Environmental Health, University of Iowa
Hans-Joachim Lehmler - Department of Occupational & Environmental Health, University of Iowa
Gabriele Ludewig - Department of Occupational & Environmental Health, University of Iowa
Keri C Hornbuckle - Department of Civil and Environmental Engineering, University of Iowa
Michael W Duffel - Department of Pharmaceutical Sciences & Experimental Therapeutics, University of Iowa
Åke Bergman - Swedish Toxicology Sciences Research Center (SWETOX)
Larry W Robertson - Department of Occupational & Environmental Health, University of Iowa
Resource Type: Journal article
Publication Details: Critical Reviews in Toxicology, Vol.45(3), pp.245-272
DOI: 10.3109/10408444.2014.999365
PMID: 25629923
PMCID: PMC4383295
NLM abbreviation: Crit Rev Toxicol
ISSN: 1040-8444
eISSN: 1547-6898
Publisher: Taylor & Francis
Language: English
Date published: 03/16/2015
Academic Unit: Pharmacy; Civil and Environmental Engineering; Occupational and Environmental Health; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Iowa Superfund Research Program; Medicinal and Natural Products Chemistry
Record Identifier: 9983806268802771

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