Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis

Weifang Chen; Miao Yu; Qing Zhang; Xingwang Hou; Wenqian Kong; Linfeng Wei; Xiaowei Mao; Jiyan Liu; Jerald L Schnoor; Guibin Jiang

doi:10.1021/acs.est.0c01830

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Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis

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Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis

Weifang Chen, Miao Yu, Qing Zhang, Xingwang Hou, Wenqian Kong, Linfeng Wei, Xiaowei Mao, Jiyan Liu, Jerald L Schnoor and Guibin Jiang

Environmental science & technology, Vol.54(16), pp.9990-9999

08/18/2020

DOI: 10.1021/acs.est.0c01830

PMID: 32600037

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https://www.ncbi.nlm.nih.gov/pmc/articles/7703871View

Open Access

Abstract

Short-chain and medium-chain chlorinated paraffins (SCCPs and MCCPs) are mixtures of complex chemical compounds with intensive usage. They are frequently detected in various environmental samples. However, the interaction between CPs and plants, especially the biotransformation behaviors of CPs within plants, is poorly understood. In this study, 1,2,5,6,9,10-hexachlorodecane (CP-4, a typical standard of individual SCCP congeners) and 52%-MCCP (a commercial mixture standard of MCCPs with 52% chlorine content by mass) were selected as representative chemicals to explore the metabolic behaviors of SCCPs and MCCPs using suspension rice cell culture exposure systems. Both 79.53% and 40.70% of CP-4 and 52%-MCCP were metabolized by suspension rice cells, respectively. A complementary suspected screening strategy based on the pair mass distances (PMD) analysis algorithm was used to study the metabolism of CPs mediated by the plant cells. Forty and 25 metabolic products for CP-4 and 52%-MCCP, respectively, were identified, including (multi-) hydroxylation, dechlorination, −HCl– elimination metabolites, (hydroxylation-) sulfation, and glycosylation conjugates. Here, we propose a comprehensive metabolic molecular network and provide insight on degradation pathways of SCCPs and MCCPs in plants for the first time, aiding in further understanding of the transformation behaviors of CPs.

Contaminants in Aquatic and Terrestrial Environments

ISRP Project 5 2020-2025

Details

Title: Subtitle: Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis
Creators: Weifang Chen - University of Chinese Academy of Sciences
Miao Yu - Icahn School of Medicine at Mount Sinai
Qing Zhang - University of Chinese Academy of Sciences
Xingwang Hou - University of Chinese Academy of Sciences
Wenqian Kong - University of Chinese Academy of Sciences
Linfeng Wei - University of Chinese Academy of Sciences
Xiaowei Mao - Jianghan University
Jiyan Liu - University of Chinese Academy of Sciences
Jerald L Schnoor - Department of Civil and Environmental Engineering
Guibin Jiang - University of Chinese Academy of Sciences
Resource Type: Journal article
Publication Details: Environmental science & technology, Vol.54(16), pp.9990-9999
DOI: 10.1021/acs.est.0c01830
PMID: 32600037
NLM abbreviation: Environ Sci Technol
ISSN: 0013-936X
eISSN: 1520-5851
Publisher: American Chemical Society
Grant note: DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: P42ES013661-12; DOI: 10.13039/501100002855, name: Ministry of Science and Technology of the People's Republic of China, award: 2018YFC1800702; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 21527901, 21677158
Language: English
Date published: 08/18/2020
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health; Iowa Superfund Research Program
Record Identifier: 9983997427002771

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