Journal article
Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women
The Journal of nutrition, Vol.153(9), pp.2651-2662
09/2023
DOI: 10.1016/j.tjnut.2023.05.021
PMCID: PMC10517226
PMID: 37245660
Abstract
The Women’s Health Initiative (WHI) randomized, controlled Dietary Modification (DM) trial of a low-fat dietary pattern suggested intervention benefits related to breast cancer, coronary heart disease (CHD), and diabetes. Here we use WHI observational data for the further insight into the chronic disease implications of adopting this type of low-fat dietary pattern.
We aim to use our earlier work on metabolomics-based biomarkers of carbohydrate and protein to develop a fat intake biomarker by subtraction; to use the resulting biomarker to develop calibration equations that adjusts self-reported fat intake for measurement error; and to study associations of biomarker-calibrated fat intake with chronic disease risk in WHI cohorts. Corresponding studies for specific fatty acids will follow separately.
Prospective disease association results are presented using WHI cohorts of postmenopausal women, aged 50-79 when enrolled at 40 U.S. clinical centers. Biomarker equations were developed using an embedded human feeding study (n=153). Calibration equations were developed using a WHI nutritional biomarker study (n=436). Calibrated intakes were associated with cancer, cardiovascular diseases, and diabetes incidence in WHI cohorts (n=81,954) over an approximate 20-year follow-up period.
A biomarker for fat density was developed by subtracting protein, carbohydrate, and alcohol densities from one. A calibration equation was developed for fat density. Hazard ratios (95% confidence intervals) for 20% higher fat density were 1.16 (1.06, 1.27) for breast cancer, 1.13 (1.02, 1.26) for CHD, and 1.19 (1.13, 1.26) for diabetes, in substantial agreement with findings from the DM trial. With control for additional dietary variables, especially fiber, fat density was no longer associated with CHD, with HR (95% confidence interval) of 1.00 (0.88, 1.13), while that for breast cancer was 1.11 (1.00, 1.24).
WlHI observational data support prior DM trial findings of low-fat dietary pattern benefits in this population of postmenopausal U.S. women.
This study is registered with clinicaltrials.gov identifier: NCT00000611.
Details
- Title: Subtitle
- Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women
- Creators
- Ross L. Prentice - Fred Hutch Cancer CenterSowmya Vasan - Fred Hutch Cancer CenterLesley F. Tinker - Fred Hutch Cancer CenterMarian L. Neuhouser - Fred Hutch Cancer CenterSandi L. Navarro - Fred Hutch Cancer CenterDaniel Raftery - University of WashingtonG.A. Nagana Gowda - University of WashingtonMary Pettinger - Fred Hutch Cancer CenterAaron K. Aragaki - Fred Hutch Cancer CenterJohanna W. Lampe - Fred Hutch Cancer CenterYing Huang - Fred Hutch Cancer CenterLinda Van Horn - Northwestern UniversityJoAnn E. Manson - Brigham and Women's HospitalRobert Wallace - University of IowaYasmin Mossavar-Rahmani - Albert Einstein College of MedicineJean Wactawski-Wende - University at Buffalo, State University of New YorkSimin Liu - Brown UniversityLinda Snetselaar - University of IowaBarbara V. Howard - Georgetown University Medical CenterRowan T. Chlebowski - Harvard UniversityCheng Zheng - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.153(9), pp.2651-2662
- DOI
- 10.1016/j.tjnut.2023.05.021
- PMID
- 37245660
- PMCID
- PMC10517226
- NLM abbreviation
- J Nutr
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005; DOI: 10.13039/100000054, name: National Cancer Institute, award: P30 CA15704, R01 CA119171, S10 OD021562; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: P30DK035816; DOI: 10.13039/100000002, name: National Institutes of Health
- Language
- English
- Electronic publication date
- 05/26/2023
- Date published
- 09/2023
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984420933202771
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