Journal article
Metabolomics Biomarkers for Fatty Acid Intake and Biomarker-Calibrated Fatty Acid Associations with Chronic Disease Risk in Postmenopausal Women1
The Journal of nutrition, Vol.153(9), pp.2663-2677
09/2023
DOI: 10.1016/j.tjnut.2023.05.003
PMCID: PMC10550839
PMID: 37178978
Abstract
A substantial observational literature relating specific fatty acid classes to chronic disease risk may be limited by its reliance on self-reported dietary data.
We aimed to develop biomarkers for saturated (SFA), monounsaturated (MFA) and polyunsaturated (PFA) fatty acid densities, and to study their associations with cardiovascular disease (CVD), cancer, and type 2 diabetes (T2D) in Women’s Health Initiative (WHI) cohorts.
Biomarker equations were based primarily on serum and urine metabolomics profiles from an embedded WHI human feeding study (n=153). Calibration equations were based on biomarker values in a WHI nutritional biomarker study (n=436). Calibrated intakes were assessed in relation to disease incidence in larger WHI cohorts (n=81,894). Participants were postmenopausal women, aged 50-79 when enrolled at 40 U.S. Clinical Centers (1993-1998), with a follow-up period of about 20 years.
Biomarker equations meeting criteria were developed for SFA, MFA, and PFA densities. That for SFA density depended somewhat weakly on metabolite profiles. Based on our metabolomics platforms, biomarkers were insensitive to trans fatty acid (TFA) intake. Calibration equations meeting criteria were developed for SFA and PFA density, but not for MFA density. With or without biomarker calibration SFA density was associated positively with the risk of CVD, cancer and T2D, but with small hazard ratios, and CVD associations were not statistically significant after controlling for other dietary variables, including TFA and fiber intake. Following this same control PFA density was not significantly associated with CVD risk, but there were positive associations for some cancers and T2D, with or without biomarker calibration.
Higher SFA and PFA diets were associated with null or somewhat higher risk for clinical outcomes considered in this population of postmenopausal U.S. women. Further research is needed to develop even stronger biomarkers for these fatty acid densities and their major components.
This study is registered with clinicaltrials.gov identifier: NCT00000611.
Details
- Title: Subtitle
- Metabolomics Biomarkers for Fatty Acid Intake and Biomarker-Calibrated Fatty Acid Associations with Chronic Disease Risk in Postmenopausal Women1
- Creators
- Ross L. Prentice - Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WASowmya Vasan - Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WALesley F. Tinker - Fred Hutch Cancer CenterMarian L. Neuhouser - Fred Hutch Cancer CenterSandi L. Navarro - Fred Hutch Cancer CenterDaniel Raftery - Fred Hutch Cancer CenterG.A. Nagana Gowda - University of WashingtonMary Pettinger - University of WashingtonAaron K. Aragaki - Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WAJohanna W. Lampe - Fred Hutch Cancer CenterYing Huang - Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WALinda Van Horn - Northwestern UniversityJoAnn E. Manson - Brigham and Women's HospitalRobert B. Wallace - University of IowaYasmin Mossavar-Rahmani - Albert Einstein College of MedicineJean Wactawski-Wende - University at Buffalo, State University of New YorkSimin Liu - Brown UniversityLinda Snetselaar - University of IowaBarbara V. Howard - Georgetown University Medical CenterRowan T. Chlebowski - The Lundquist Institute, Torrance, CACheng Zheng - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.153(9), pp.2663-2677
- DOI
- 10.1016/j.tjnut.2023.05.003
- PMID
- 37178978
- PMCID
- PMC10550839
- NLM abbreviation
- J Nutr
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100005895, name: Fred Hutchinson Cancer Research Center; DOI: 10.13039/100000002, name: National Institutes of Health, award: S10 OD021562; DOI: 10.13039/100007812, name: University of Washington; DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services, award: HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C, HHSN268201600046C, HHSN271201600004C; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000054, name: National Cancer Institute, award: P30 CA15704, R01 CA119171; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: P30DK035816
- Language
- English
- Electronic publication date
- 05/11/2023
- Date published
- 09/2023
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984410801002771
Metrics
16 Record Views