Journal article
Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients
Annals of surgical oncology, Vol.23(9), pp.2883-2888
09/01/2016
DOI: 10.1245/s10434-016-5245-9
PMID: 27146414
Abstract
Background
Metadherin (MTDH) is widely recognized as a promising molecular marker for tumor recurrence and poor survival in many cancers. By multiple pathways, MTDH promotes oncogenesis, metastasis, and chemoresistance. This study investigated the role of MTDH in papillary thyroid carcinoma (PTC) to determine its potential association with aggressive clinical and pathologic features, including its relation in tumors harboring a
BRAF
V600E
mutation.
Methods
Expression of MTDH was assessed by immunohistochemistry in 96 cases of PTC, including primary thyroid malignancies and lymph node metastases. The status of
BRAF
V600E
mutation was determined by real-time polymerase chain reaction.
Results
Overexpression of MTDH was observed in 26 % (23/88) of primary PTC cases. High-intensity staining was observed in 75 % (6/8) of lymph nodes with metastatic PTC and moderate staining in 25 % (2/8) of cases. Normal adjacent thyroid tissue and benign thyroid controls were found to have significantly lower MTDH expression than cancer tissue (
p
< 0.05). Apical staining of MTDH was observed in 19 % of thyroid tumors and not observed in normal thyroid tissue. Interestingly, MTDH expression was associated with extrathyroidal extension (
p
< 0.05) and not associated with age, gender, overall tumor stage, or
BRAF
V600E
mutation status.
Conclusion
In a subset of PTC patients, MTDH was overexpressed and associated with extrathyroidal extension. Further studies are warranted to explore the utility of MTDH to improve risk stratification of current molecular panels for PTC.
Details
- Title: Subtitle
- Metadherin Expression is Associated with Extrathyroidal Extension in Papillary Thyroid Cancer Patients
- Creators
- Robert F. Moore - Tulane UniversityAndrew B. Sholl - Tulane UniversityLaura Kidd - Tulane UniversityZaid Al-Qurayshi - Tulane UniversityKoji Tsumagari - Tulane UniversityObinwanne M. Emejulu - Tulane UniversityRoostam Kholmatov - Tulane UniversityPaul Friedlander - Tulane UniversityZakaria Y. Abd Elmageed - Tulane UniversityEmad Kandil - Tulane University
- Resource Type
- Journal article
- Publication Details
- Annals of surgical oncology, Vol.23(9), pp.2883-2888
- Publisher
- Springer International Publishing
- DOI
- 10.1245/s10434-016-5245-9
- PMID
- 27146414
- ISSN
- 1068-9265
- eISSN
- 1534-4681
- Number of pages
- 6
- Language
- English
- Date published
- 09/01/2016
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984702823802771
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