Journal article
Metal homeostasis in pathogenic Epsilonproteobacteria: mechanisms of acquisition, efflux, and regulation
Metallomics, Vol.13(1), 002
01/16/2021
DOI: 10.1093/mtomcs/mfaa002
PMCID: PMC8043183
PMID: 33570133
Abstract
Epsilonproteobacteria are a diverse class of eubacteria within the Proteobacteria phylum that includes environmental sulfur-reducing bacteria and the human pathogens, Campylobacter jejuni and Helicobacter pylori. These pathogens infect and proliferate within the gastrointestinal tracts of multiple animal hosts, including humans, and cause a variety of disease outcomes. While infection of these hosts provides nutrients for the pathogenic Epsilonproteobacteria, many hosts have evolved a variety of strategies to either sequester metals from the invading pathogen or exploit the toxicity of metals and drive their accumulation as an antimicrobial strategy. As a result, C. jejuni and H. pylori have developed mechanisms to sense changes in metal availability and regulate their physiology in order to respond to either metal limitation or accumulation. In this review, we will discuss the challenges of metal availability at the host-pathogen interface during infection with C. jejuni and H. pylori and describe what is currently known about how these organisms alter their gene expression and/or deploy bacterial virulence factors in response to these environments.
Details
- Title: Subtitle
- Metal homeostasis in pathogenic Epsilonproteobacteria: mechanisms of acquisition, efflux, and regulation
- Creators
- Brittni R. Kelley - University of Tennessee at KnoxvilleJacky Lu - Vanderbilt UniversityKathryn P. Haley - Grand Valley State UniversityJennifer A. Gaddy - Vanderbilt UniversityJeremiah G. Johnson - University of Tennessee at Knoxville
- Resource Type
- Journal article
- Publication Details
- Metallomics, Vol.13(1), 002
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/mtomcs/mfaa002
- PMID
- 33570133
- PMCID
- PMC8043183
- ISSN
- 1756-5901
- eISSN
- 1756-591X
- Number of pages
- 19
- Grant note
- IK2BX001701 / Office of Medical Research, Department of Veterans Affairs; US Department of Veterans Affairs P30DK058404 / Vanderbilt University Medical Center's Digestive Disease Research Center - NIH 2 UL1 TR000445-06 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) UL1 RR024975-01 / Vanderbilt Institute for Clinical and Translational Research program - the National Center for Research Resources
- Language
- English
- Date published
- 01/16/2021
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984696724802771
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