Journal article
Metastasis as a Multiorgan Disease: Toward Organ-Informed Precision Oncology
Cancer discovery, Vol.16(4), pp.656-659
04/01/2026
DOI: 10.1158/2159-8290.CD-25-2052
PMID: 41918349
Abstract
Metastasis is a multiorgan disease in which disseminated cancer cells undergo profound, tissue-specific reprogramming that reshapes their identity, vulnerabilities, and therapeutic responses. We argue for an organ-informed precision oncology framework that integrates these site-imposed programs into treatment design.
Details
- Title: Subtitle
- Metastasis as a Multiorgan Disease: Toward Organ-Informed Precision Oncology
- Creators
- Anish Thomas - National Cancer InstituteChirayu Mohindroo - National Cancer InstituteYue Huang - National Cancer InstituteJulien Sage - Stanford MedicineJoan Massague - Memorial Sloan Kettering Cancer Center
- Resource Type
- Journal article
- Publication Details
- Cancer discovery, Vol.16(4), pp.656-659
- DOI
- 10.1158/2159-8290.CD-25-2052
- PMID
- 41918349
- ISSN
- 2159-8274
- eISSN
- 2159-8290
- Publisher
- Amer Assoc Cancer Research
- Number of pages
- 4
- Grant note
- NCI ZIA BC 011793 / NIH Intramural Research Program; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P01-CA129243; U54-CA209975; P30-CA008748; R01-CA285740; R35-CA231977 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 04/01/2026
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985178657502771
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