Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature

Michael Garneau; Eyas Alyzadneh; Geeta Lal; Anand Rajan Kd

doi:10.1007/s12105-022-01509-7

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Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature

Journal article

Open access

Peer reviewed

Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature

Michael Garneau, Eyas Alyzadneh, Geeta Lal and Anand Rajan Kd

Head & neck pathology (Totowa, N.J.), Vol.17(2), pp.447-459

06/2023

DOI: 10.1007/s12105-022-01509-7

PMCID: PMC10293528

PMID: 36719557

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293528View

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Abstract

Metastatic disease to the thyroid gland is uncommon but well-described. Metastatic disease to a concurrent primary thyroid neoplasm is a rare phenomenon. We sought to study patients with metastasis to the thyroid with a focus on the histopathologic and clinical features in tumor-to-tumor metastasis. We identified a series of patients with metastatic disease to the thyroid, with or without a concurrent primary neoplasm, through a search of the files of the Department of Pathology. All relevant slides were retrieved and reviewed, including routine HE and immunohistochemical stains. We performed a detailed English language literature search (1962-2022) and review to identify tumor-to-tumor metastasis involving the thyroid. We identified 14 patients with metastasis to the thyroid over a 22-year period. Four patients exhibited papillary thyroid carcinoma, with metastatic spread of a different malignancy seeding into the thyroid cancer. We describe the histopathologic diagnostic process and findings, clinical management, and the clinical course of tumor-to-tumor metastasis in greater detail for these 4 patients. Tumor-to-tumor metastasis to the thyroid is a rare event with unique histopathologic features. Our findings suggest that the phenomenon of tumor-to-tumor metastasis serves to highlight broader mechanisms of metastatic disease in general. We provide the largest-to-date and comprehensive review of the literature to identify all previous reported instances of tumor-to-tumor metastasis involving the thyroid.

Metastasis to thyroid

Tumor-to-tumor metastasis

Papillary thyroid carcinoma

Thyroid metastasis

Details

Title: Subtitle: Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature
Creators: Michael Garneau - Roy J. and Lucille A. Carver College of Medicine
Eyas Alyzadneh - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA
Geeta Lal - University of Iowa
Anand Rajan Kd - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA. anand-rajand@uiowa.edu
Resource Type: Journal article
Publication Details: Head & neck pathology (Totowa, N.J.), Vol.17(2), pp.447-459
DOI: 10.1007/s12105-022-01509-7
PMID: 36719557
PMCID: PMC10293528
NLM abbreviation: Head Neck Pathol
eISSN: 1936-0568
Language: English
Electronic publication date: 01/31/2023
Date published: 06/2023
Academic Unit: Stead Family Department of Pediatrics; Pathology; Surgery
Record Identifier: 9984364650702771

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