Journal article
Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature
Head & neck pathology (Totowa, N.J.), Vol.17(2), pp.447-459
01/31/2023
DOI: 10.1007/s12105-022-01509-7
PMCID: PMC10293528
PMID: 36719557
Abstract
Metastatic disease to the thyroid gland is uncommon but well-described. Metastatic disease to a concurrent primary thyroid neoplasm is a rare phenomenon. We sought to study patients with metastasis to the thyroid with a focus on the histopathologic and clinical features in tumor-to-tumor metastasis.
We identified a series of patients with metastatic disease to the thyroid, with or without a concurrent primary neoplasm, through a search of the files of the Department of Pathology. All relevant slides were retrieved and reviewed, including routine HE and immunohistochemical stains. We performed a detailed English language literature search (1962-2022) and review to identify tumor-to-tumor metastasis involving the thyroid.
We identified 14 patients with metastasis to the thyroid over a 22-year period. Four patients exhibited papillary thyroid carcinoma, with metastatic spread of a different malignancy seeding into the thyroid cancer. We describe the histopathologic diagnostic process and findings, clinical management, and the clinical course of tumor-to-tumor metastasis in greater detail for these 4 patients.
Tumor-to-tumor metastasis to the thyroid is a rare event with unique histopathologic features. Our findings suggest that the phenomenon of tumor-to-tumor metastasis serves to highlight broader mechanisms of metastatic disease in general. We provide the largest-to-date and comprehensive review of the literature to identify all previous reported instances of tumor-to-tumor metastasis involving the thyroid.
Details
- Title: Subtitle
- Metastatic Disease to a Concurrent Thyroid Neoplasm: A Case Series and Review of the Literature
- Creators
- Michael Garneau - Roy J. and Lucille A. Carver College of MedicineEyas Alyzadneh - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USAGeeta Lal - University of IowaAnand Rajan Kd - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA. anand-rajand@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Head & neck pathology (Totowa, N.J.), Vol.17(2), pp.447-459
- DOI
- 10.1007/s12105-022-01509-7
- PMID
- 36719557
- PMCID
- PMC10293528
- eISSN
- 1936-0568
- Language
- English
- Electronic publication date
- 01/31/2023
- Academic Unit
- Stead Family Department of Pediatrics; Pathology; Surgery
- Record Identifier
- 9984364650702771
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