Journal article
Metastatic renal cell carcinoma to the pancreas and other sites—a multicenter retrospective study
EClinicalMedicine, Vol.60, pp.102018-102018
06/2023
DOI: 10.1016/j.eclinm.2023.102018
PMCID: PMC10248040
PMID: 37304495
Abstract
Metastatic renal cell carcinoma (mRCC) is a heterogenous disease with poor 5-year overall survival (OS) at 14%. Patients with mRCC to endocrine organs historically have prolonged OS. Pancreatic metastases are uncommon overall, with mRCC being the most common etiology of pancreatic metastases. In this study, we report the long-term outcomes of patients with mRCC to the pancreas in two separate cohorts.
We performed a multicenter, international retrospective cohort study of patients with mRCC to the pancreas at 15 academic centers. Cohort 1 included 91 patients with oligometastatic disease to the pancreas. Cohort 2 included 229 patients with multiples organ sites of metastases including the pancreas. The primary endpoint for Cohorts 1 and 2 was median OS from time of metastatic disease in the pancreas until death or last follow up.
In Cohort 1, the median OS (mOS) was 121 months with a median follow up time of 42 months. Patients who underwent surgical resection of oligometastatic disease had mOS of 100 months with a median follow-up time of 52.5 months. The mOS for patients treated with systemic therapy was not reached. In Cohort 2, the mOS was 90.77 months. Patients treated with first-line (1L) VEGFR therapy had mOS of 90.77 months; patients treated with IL immunotherapy (IO) had mOS of 92 months; patients on 1L combination VEGFR/IO had mOS of 74.9 months.
This is the largest retrospective cohort of mRCC involving the pancreas. We confirmed the previously reported long-term outcomes in patients with oligometastatic pancreas disease and demonstrated prolonged survival in patients with multiple RCC metastases that included the pancreas. In this retrospective study with heterogeneous population treated over 2 decades, mOS was similar when stratified by first-line therapy. Future research will be needed to determine whether mRCC patients with pancreatic metastases require a different initial treatment strategy.
Statistical analyses for this study were supported in part by the University of Colorado Cancer Center Support Grant from the NIH/NCI, P30CA046934-30.
Details
- Title: Subtitle
- Metastatic renal cell carcinoma to the pancreas and other sites—a multicenter retrospective study
- Creators
- Cassandra Duarte - University of Colorado DenverJunxiao Hu - University of Colorado Cancer CenterBenoit Beuselinck - KU LeuvenJustine Panian - University of California San DiegoNicole Weise - University of California San DiegoNazli Dizman - City Of Hope National Medical CenterKatharine A. Collier - The Ohio State UniversityNityam Rathi - Huntsman Cancer InstituteHaoran Li - Huntsman Cancer InstituteRoy Elias - The University of Texas Southwestern Medical CenterNieves Martinez-Chanza - Institut Jules BordetTracy L. Rose - UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USALauren C. Harshman - Cambridge Scientific (United States)Dharmesh Gopalakrishnan - Roswell Park Cancer InstituteUlka Vaishampayan - The Barbara Ann Karmanos Cancer InstituteYousef Zakharia - University of IowaVivek Narayan - University of PennsylvaniaBenedito A. Carneiro - Brown UniversityAnthony Mega - Brown UniversityNirmish Singla - The University of Texas Southwestern Medical CenterCheryl Meguid - University of Colorado Cancer CenterSaby George - Roswell Park Cancer InstituteJames Brugarolas - The University of Texas Southwestern Medical CenterNeeraj Agarwal - University of UtahAmir Mortazavi - The Ohio State UniversitySumanta Pal - City Of Hope National Medical CenterRana R. McKay - University of California San DiegoElaine T. Lam - University of Colorado Cancer Center
- Resource Type
- Journal article
- Publication Details
- EClinicalMedicine, Vol.60, pp.102018-102018
- DOI
- 10.1016/j.eclinm.2023.102018
- PMID
- 37304495
- PMCID
- PMC10248040
- NLM abbreviation
- EClinicalMedicine
- ISSN
- 2589-5370
- eISSN
- 2589-5370
- Publisher
- Elsevier Ltd
- Grant note
- University of Colorado Cancer Center (https://doi.org/10.13039/100013678) P30CA046934-30 / NCI (https://doi.org/10.13039/100000054) NIH (https://doi.org/10.13039/100000002)
- Language
- English
- Date published
- 06/2023
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984544951002771
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