Logo image
Back
Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder
Journal article   Peer reviewed

Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder

L. Fredrik Jarskog, Robert M Hamer, Diane J Catellier, Dawn D Stewart, Lisa Lavange, Neepa Ray, Lauren H Golden, Jeffrey A Lieberman, T. Scott Stroup and METS Investigators
The American journal of psychiatry, Vol.170(9), pp.1032-1040
2013
DOI: 10.1176/appi.ajp.2013.12010127
PMCID: PMC3874085
PMID: 23846733
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3874085View
Open Access

Abstract

Objective The purpose of this study was to determine whether metformin promotes weight loss in overweight outpatients with chronic schizophrenia or schizoaffective disorder. Method In a double-blind study, 148 clinically stable, overweight (body mass index [BMI] ≥27) outpatients with chronic schizophrenia or schizoaffective disorder were randomly assigned to receive 16 weeks of metformin or placebo. Metformin was titrated up to 1,000 mg twice daily, as tolerated. All patients continued to receive their prestudy medications, and all received weekly diet and exercise counseling. The primary outcome measure was change in body weight from baseline to week 16. Results Fifty-eight (77.3%) patients who received metformin and 58 (81.7%) who received placebo completed 16 weeks of treatment. Mean change in body weight was −3.0 kg (95% CI=−4.0 to −2.0) for the metformin group and −1.0 kg (95% CI=−2.0 to 0.0) for the placebo group, with a between-group difference of −2.0 kg (95% CI=−3.4 to −0.6). Metformin also demonstrated a significant between-group advantage for BMI (−0.7; 95% CI=−1.1 to −0.2), triglyceride level (−20.2 mg/dL; 95% CI=−39.2 to −1.3), and hemoglobin A1c level (−0.07%; 95% CI=−0.14 to −0.004). Metformin-associated side effects were mostly gastrointestinal and generally transient, and they rarely led to treatment discontinuation. Conclusions Metformin was modestly effective in reducing weight and other risk factors for cardiovascular disease in clinically stable, overweight outpatients with chronic schizophrenia or schizoaffective disorder over 16 weeks. A significant time-by-treatment interaction suggests that benefits of metformin may continue to accrue with longer treatment. Metformin may have an important role in diminishing the adverse consequences of obesity and metabolic impairments in patients with schizophrenia.
 Obesity Schizophrenia Adult and adolescent clinical studies Biological and medical sciences Medical sciences Metabolic diseases Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses

Details

Metrics

11 Record Views
101 Times Cited - Web of Science
Logo image