Journal article
Methacrylic monomer derived from cardanol incorporated in dental adhesive as a polymerizable collagen crosslinker
Dental materials, Vol.38(10), pp.1610-1622
10/01/2022
DOI: 10.1016/j.dental.2022.08.008
PMID: 36050192
Abstract
Objectives: The aim of this study was to evaluate the influence on MMP inhibition, dentin adhesion and physicochemical properties of an adhesive system incorporated with poly-merizable collagen crosslinker monomer derived from cardanol.Methods: The intermediary cardanol epoxy (CNE) was synthesized through cardanol epoxidation, followed by synthesis of cardanol methacrylate through methacrylic acid solvent-free esterification. Zymographic analysis was performed to evaluate the sub-stances' ability to inhibit gelatinolytic enzymes. Collagen crosslinkers were added into adhesives systems according to the following groups: Ybond Universal (R) (Control), Ybond (R) + 2 % proanthocyanidin (PAC), Ybond (R) + 2 % unsaturated cardanol (Cardanol) and Ybond (R) + 2 % cardanol methacrylate (CNMA). Degree of conversion (DC) of the adhesives was as-sessed by FT-IR. Disk-shaped specimens were prepared for water sorption (WS) and solu-bility (SL) tests. Human third molars were sectioned to expose medium dentin and restored according to the different adhesives used (n = 5). Then, the specimens were cut into 1 mm2 sticks to evaluate, after 24 h and 6-month aging, microtensile bond strength (mu TBS) and nanoleakage by scanning electron microscopy. Data were analysed with ANOVA and Tukey's post-test (alpha = 0.05).Results: CNMA and PAC completely inhibited all forms of gelatinolytic enzymes. Cardanol achieved a significantly lowest DC, while the other groups did not differ from each other (p > 0.05). PAC achieved significantly higher water sorption, while CNMA solubility was significantly lower when compared to the other adhesives (p < 0.05). PAC provided a statistically higher 24 h and 6-month aging bond strength. Intermediary similar mu TBS were presented by control and CNMA (p = 0.108). All adhesives applied attained significantly reduced bond strength after aging (p < 0.05). Interfaces created using CNMA were almost devoid of silver deposits initially, however all groups showed large amounts of silver de-posits on resin-dentin interface subjected to water aging.Significance: Although CNMA was effective in inhibiting gelatinolytic enzymes, when in-corporated into a universal adhesive it could not promote less degradation of the adhesive interface after water aging. Since it is a hydrophobic monomer, CNMA did not interact well with dentin collagen, however it reduced the solubility of the adhesive system besides not interfering in its polymerization.(c) 2022 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Methacrylic monomer derived from cardanol incorporated in dental adhesive as a polymerizable collagen crosslinker
- Creators
- Madiana Magalhaes Moreira - Federal ReserveManuela Timbo Farrapo - Paulo Picanco Sch Dent, Fortaleza, BrazilRita de Cassia Sousa Pereira - Univ Fed Ceara, Dept Organ & Inorgan Chem, Fortaleza, BrazilLucas Renan Rocha da Silva - Universidade Federal do CearáGarrit Koller - King's College LondonTimothy Watson - King's College LondonVictor Pinheiro Feitosa - Paulo Picanco Sch Dent, Fortaleza, BrazilDiego Lomonaco - Universidade Federal do Ceará
- Resource Type
- Journal article
- Publication Details
- Dental materials, Vol.38(10), pp.1610-1622
- Publisher
- Elsevier
- DOI
- 10.1016/j.dental.2022.08.008
- PMID
- 36050192
- ISSN
- 0109-5641
- eISSN
- 1879-0097
- Number of pages
- 13
- Grant note
- FUNCAP; Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (FUNCAP) CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) CAPES; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Finep-CT-INFRA; Financiadora de Inovacao e Pesquisa (Finep)
- Language
- English
- Date published
- 10/01/2022
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984655343102771
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