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Methicillin-resistant S. aureus infections among patients in the emergency department
Journal article   Open access   Peer reviewed

Methicillin-resistant S. aureus infections among patients in the emergency department

Gregory J Moran, Anusha Krishnadasan, Rachel J Gorwitz, Gregory E Fosheim, Linda K McDougal, Roberta B Carey, David A Talan and EMERGEncy ID Net Study Group
The New England journal of medicine, Vol.355(7), pp.666-674
08/17/2006
DOI: 10.1056/NEJMoa055356
PMID: 16914702
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https://doi.org/10.1056/NEJMoa055356View
Published (Version of record) Open Access

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA. We enrolled adult patients with acute, purulent skin and soft-tissue infections presenting to 11 university-affiliated emergency departments during the month of August 2004. Cultures were obtained, and clinical information was collected. Available S. aureus isolates were characterized by antimicrobial-susceptibility testing, pulsed-field gel electrophoresis, and detection of toxin genes. On MRSA isolates, we performed typing of the staphylococcal cassette chromosome mec (SCCmec), the genetic element that carries the mecA gene encoding methicillin resistance. S. aureus was isolated from 320 of 422 patients with skin and soft-tissue infections (76 percent). The prevalence of MRSA was 59 percent overall and ranged from 15 to 74 percent. Pulsed-field type USA300 isolates accounted for 97 percent of MRSA isolates; 74 percent of these were a single strain (USA300-0114). SCCmec type IV and the Panton-Valentine leukocidin toxin gene were detected in 98 percent of MRSA isolates. Other toxin genes were detected rarely. Among the MRSA isolates, 95 percent were susceptible to clindamycin, 6 percent to erythromycin, 60 percent to fluoroquinolones, 100 percent to rifampin and trimethoprim-sulfamethoxazole, and 92 percent to tetracycline. Antibiotic therapy was not concordant with the results of susceptibility testing in 100 of 175 patients with MRSA infection who received antibiotics (57 percent). Among methicillin-susceptible S. aureus isolates, 31 percent were USA300 and 42 percent contained pvl genes. MRSA is the most common identifiable cause of skin and soft-tissue infections among patients presenting to emergency departments in 11 U.S. cities. When antimicrobial therapy is indicated for the treatment of skin and soft-tissue infections, clinicians should consider obtaining cultures and modifying empirical therapy to provide MRSA coverage.
 United States Acute Disease Adult Aged Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacterial Proteins - genetics Bacterial Toxins - genetics Electrophoresis, Gel, Pulsed-Field Emergency Service, Hospital Exotoxins - genetics Female Humans Leukocidins Male Methicillin Resistance - genetics Microbial Sensitivity Tests Middle Aged Penicillin-Binding Proteins Soft Tissue Infections - drug therapy Soft Tissue Infections - microbiology Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal Skin Infections - drug therapy Staphylococcal Skin Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - genetics

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