Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci co-colonization

Jon P Furuno; Eli N Perencevich; Judith A Johnson; Marc-Oliver Wright; Jessina C McGregor; J Glenn Morris Jr; Sandra M Strauss; Mary-Claire Roghman; Lucia L Nemoy; Harold C Standiford; Joan N Hebden; Anthony D Harris

doi:10.3201/eid1110.050508

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Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci co-colonization

Journal article

Open access

Peer reviewed

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci co-colonization

Jon P Furuno, Eli N Perencevich, Judith A Johnson, Marc-Oliver Wright, Jessina C McGregor, J Glenn Morris Jr, Sandra M Strauss, Mary-Claire Roghman, Lucia L Nemoy, Harold C Standiford, …

Emerging infectious diseases, Vol.11(10), pp.1539-1544

10/2005

DOI: 10.3201/eid1110.050508

PMCID: PMC3366750

PMID: 16318693

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Abstract

We assessed the prevalence, risk factors, and clinical outcomes of patients co-colonized with vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) upon admission to the medical and surgical intensive care units (ICUs) of a tertiary-care facility between January 1, 2002, and December 31, 2003. Co-colonization was defined as a VRE-positive perirectal surveillance culture with an MRSA-positive anterior nares surveillance culture collected concurrently. Among 2,440 patients, 65 (2.7%) were co-colonized. Independent risk factors included age (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.01-1.05), admission to the medical ICU (OR 4.38, 95% CI 2.46-7.81), male sex (OR 1.93, 95% CI 1.14-3.30), and receiving antimicrobial drugs on a previous admission within 1 year (OR 3.06, 95% CI 1.85-5.07). None of the co-colonized patients would have been identified with clinical cultures alone. We report a high prevalence of VRE/MRSA co-colonization upon admission to ICUs at a tertiary-care hospital.

Intensive Care Units

Prevalence

Staphylococcus aureus - isolation & purification

Cross Infection - prevention & control

Humans

Middle Aged

Risk Factors

Vancomycin Resistance

Male

Staphylococcal Infections - complications

Gram-Positive Bacterial Infections - epidemiology

Staphylococcal Infections - epidemiology

Cross Infection - microbiology

Enterococcus - isolation & purification

Gram-Positive Bacterial Infections - microbiology

Female

Aged

Enterococcus - drug effects

Staphylococcal Infections - microbiology

Gram-Positive Bacterial Infections - complications

Methicillin Resistance

Staphylococcus aureus - drug effects

Details

Title: Subtitle: Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci co-colonization
Creators: Jon P Furuno - University of Maryland, Baltimore
Eli N Perencevich
Judith A Johnson
Marc-Oliver Wright
Jessina C McGregor
J Glenn Morris Jr
Sandra M Strauss
Mary-Claire Roghman
Lucia L Nemoy
Harold C Standiford
Joan N Hebden
Anthony D Harris
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.11(10), pp.1539-1544
DOI: 10.3201/eid1110.050508
PMID: 16318693
PMCID: PMC3366750
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Publisher: United States
Grant note: K23 AI001752 / NIAID NIH HHS K23 AI01752-01A1 / NIAID NIH HHS
Language: English
Date published: 10/2005
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983779290002771

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