Journal article
Methicillin-resistant Staphylococcus aureus has greater risk of transmission in the operating room than methicillin-sensitive S aureus
AJIC: American Journal of Infection Control, Vol.46(5), pp.520-525
05/2018
DOI: 10.1016/j.ajic.2017.11.002
PMID: 29307750
Abstract
•Staphylococcus aureus pathogens are frequently transmitted in the operating room environment.•Methicillin-resistant S aureus is more transmissible than methicillin-sensitive S aureus. Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic S aureus strain characteristic associated with increased patient morbidity and mortality. The health care system needs to understand MRSA transmissibility in all settings to improve basic preventive measures to generate sustained reductions in invasive MRSA infections. Our primary aim was to compare intraoperative transmissibility of MRSA versus methicillin-sensitive S aureus (MSSA) isolates. S aureus isolates (N = 173) collected from 274 randomly selected operating room environments (first and second case of the day in each operating room, a case pair) at 3 hospitals underwent systematic-phenotypic and genomic processing to identify clonally related transmission events. Confirmed transmission events were defined as at least 2 S aureus isolates obtained from ≥2 distinct intraoperative reservoirs sampled within or between cases in a study unit that were epidemiologically and clonally related. We explored the relationship between clonal transmission and methicillin resistance with Poisson regression analysis. We identified 58 clonal transmission events. MRSA isolates were associated with increased risk of clonal transmission compared with MSSA isolates (adjusted incidence risk ratio [IRR], 1.68; 95% confidence interval [CI], 1.13-2.49; P = .010; unadjusted IRR, 1.85; 95% CI, 1.23-2.77; P = .003, respectively). MRSA isolates are associated with increased risk of intraoperative transmission. Future work should examine the impact of the attenuation of intraoperative MRSA transmission on the incidence of invasive MRSA infections.
Details
- Title: Subtitle
- Methicillin-resistant Staphylococcus aureus has greater risk of transmission in the operating room than methicillin-sensitive S aureus
- Creators
- Randy W Loftus - Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IAFranklin Dexter - Department of Anesthesia, University of Iowa, Iowa City, IAAlysha D.M Robinson - Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- AJIC: American Journal of Infection Control, Vol.46(5), pp.520-525
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.ajic.2017.11.002
- PMID
- 29307750
- ISSN
- 0196-6553
- eISSN
- 1527-3296
- Grant note
- The University of Iowa
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Health Management and Policy; Anesthesia
- Record Identifier
- 9983806264102771
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