Journal article
Methionine as a double-edged sword in health and disease: Current perspective and future challenges
Ageing research reviews, Vol.72, pp.101500-101500
12/2021
DOI: 10.1016/j.arr.2021.101500
PMID: 34700006
Abstract
Methionine is one of the essential amino acids and plays a vital role in various cellular processes. Reports advocate that methionine restriction and supplementation provide promising outcomes, and its regulation is critical for maintaining a healthy life. Dietary methionine restriction in houseflies and rodents has been proven to extend lifespan. Contrary to these findings, long-term dietary restriction of methionine leads to adverse events such as bone-related disorders, stunted growth, and hyperhomocysteinemia. Conversely, dietary supplementation of methionine improves hepatic steatosis, insulin resistance, inflammation, fibrosis, and bone health. However, a high level of methionine intake shows adverse effects such as hyperhomocysteinemia, reduced body weight, and increased cholesterol levels. Therefore, dietary methionine in a safe dose could have medicinal values. Hence, this review is aimed to provide a snapshot of the dietary role and regulation of methionine in the modulation of health and age-related diseases.
•Methionine is an essential amino acid and plays a crucial role in modulation of health.•Methionine restriction has both beneficial and detrimental effects.•Likewise, supplementation of methionine possesses both protective and destructive effects.•The usage of methionine as a dietary intervention in safer limits could have medicinal values and can modulates the aging process.
Details
- Title: Subtitle
- Methionine as a double-edged sword in health and disease: Current perspective and future challenges
- Creators
- Umashanker Navik - Central University of PunjabVaibhav G. Sheth - National Institute of Pharmaceutical Education and ResearchAmit Khurana - Indian Institute of Technology IndoreSnehal Sainath Jawalekar - National Institute of Pharmaceutical Education and ResearchPrince Allawadhi - Pandit Bhagwat Dayal Sharma University of Health SciencesRavinder Reddy Gaddam - University of IowaJasvinder Singh Bhatti - Central University of PunjabKulbhushan Tikoo - National Institute of Pharmaceutical Education and Research
- Resource Type
- Journal article
- Publication Details
- Ageing research reviews, Vol.72, pp.101500-101500
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.arr.2021.101500
- PMID
- 34700006
- ISSN
- 1568-1637
- eISSN
- 1872-9649
- Grant note
- DOI: 10.13039/100016045, name: University of Central Punjab; DOI: 10.13039/501100000828, name: Royal Society of Medicine; DOI: 10.13039/501100001410, name: CSIR HRDG; DOI: 10.13039/501100001412, name: Council of Scientific and Industrial Research, India
- Language
- English
- Date published
- 12/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984446447402771
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