Journal article
Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging
Journal of the American Geriatrics Society (JAGS), Vol.63(12), pp.2519-2525
12/2015
DOI: 10.1111/jgs.13830
PMCID: PMC4906951
PMID: 26566992
Abstract
To examine the effect of the relationship between alcohol and cigarette consumption on biological aging using deoxyribonucleic acid methylation-based indices.
Hierarchical linear regression modeling followed by fitting of higher-order effects.
Longitudinal studies of aging and the effect of psychosocial stress.
Participants in two ethnically informative cohorts (n = 656 white, n = 180 black).
Deviation of biological age from chronological age as a result of smoking and alcohol consumption.
Greater cigarette consumption was associated with accelerated biological aging, with strong effects evident at even low levels of exposure. In contrast, alcohol consumption was associated with a mixed effect on biological aging and pronounced nonlinear effects. At low and heavy levels of alcohol consumption, there was accelerated biological aging, whereas at intermediate levels of consumption there was a relative decelerating effect. The decelerating effects of alcohol were particularly notable at loci for which methylation increased with age.
These data support prior epidemiological studies indicating that moderate alcohol use is associated with healthy aging, but we urge caution in interpreting these results. Conversely, smoking has strong negative effects at all levels of consumption. These results also support the use of methylomic indices as a tool for assessing the impact of lifestyle on aging.
Details
- Title: Subtitle
- Methylomic Aging as a Window onto the Influence of Lifestyle: Tobacco and Alcohol Use Alter the Rate of Biological Aging
- Creators
- Steven R H Beach - Center for Family Research, University of Georgia, Athens, GeorgiaMeeshanthini V Dogan - Department of Psychiatry, University of Iowa, Iowa City, IowaMan-Kit Lei - Center for Family Research, University of Georgia, Athens, GeorgiaCarolyn E Cutrona - Department of Psychology, Iowa State University, Ames, IowaMeg Gerrard - Department of Psychology, University of Connecticut, Storrs, ConnecticutFrederick X Gibbons - Department of Psychology, University of Connecticut, Storrs, ConnecticutRonald L Simons - Department of Sociology, Center for Family Research, University of Georgia, Athens, GeorgiaGene H Brody - Center for Family Research, University of Georgia, Athens, GeorgiaRobert A Philibert - Department of Psychiatry, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.63(12), pp.2519-2525
- Publisher
- United States
- DOI
- 10.1111/jgs.13830
- PMID
- 26566992
- PMCID
- PMC4906951
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Grant note
- P30 DA027827 / NIDA NIH HHS R21 DA034457 / NIDA NIH HHS
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984070575602771
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