Logo image
Back
Methylotroph Infections and Chronic Granulomatous Disease
Journal article   Open access   Peer reviewed

Methylotroph Infections and Chronic Granulomatous Disease

E Liana Falcone, Jennifer R Petts, Mary Beth Fasano, Bradley Ford, William M Nauseef, João Farela Neves, Maria João Simões, Millard L Tierce IV, M Teresa de la Morena, David E Greenberg, …
Emerging infectious diseases, Vol.22(3), pp.404-409
03/2016
DOI: 10.3201/eid2203.151265
PMCID: PMC4766906
PMID: 26886412
url
https://doi.org/10.3201/eid2203.151265View
Published (Version of record) Open Access

Abstract

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by a defect in production of phagocyte-derived reactive oxygen species, which leads to recurrent infections with a characteristic group of pathogens not previously known to include methylotrophs. Methylotrophs are versatile environmental bacteria that can use single-carbon organic compounds as their sole source of energy; they rarely cause disease in immunocompetent persons. We have identified 12 infections with methylotrophs (5 reported here, 7 previously reported) in patients with CGD. Methylotrophs identified were Granulibacter bethesdensis (9 cases), Acidomonas methanolica (2 cases), and Methylobacterium lusitanum (1 case). Two patients in Europe died; the other 10, from North and Central America, recovered after prolonged courses of antimicrobial drug therapy and, for some, surgery. Methylotrophs are emerging as disease-causing organisms in patients with CGD. For all patients, sequencing of the 16S rRNA gene was required for correct diagnosis. Geographic origin of the methylotroph strain may affect clinical management and prognosis.
 Europe Acetobacteraceae Communicable Diseases, Emerging - microbiology Humans Infant Male Methylobacterium Gram-Negative Bacterial Infections - microbiology Young Adult Granulomatous Disease, Chronic - microbiology Adolescent Adult Female Child

Details

Metrics

18 Record Views
17 Times Cited - Web of Science
Logo image