Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors

Karie E Scrogin; Alan Kim Johnson; Virginia L Brooks

doi:10.1152/ajpregu.2000.279.5.r1776

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Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors

Journal article

Peer reviewed

Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors

Karie E Scrogin, Alan Kim Johnson and Virginia L Brooks

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.279(5), pp.R1776-R1786

11/2000

DOI: 10.1152/ajpregu.2000.279.5.r1776

PMID: 11049861

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Abstract

Central administration of the serotonin receptor ligand methysergide delays the decompensatory response to hypotensive hemorrhage. This study was performed to determine the receptor subtype that mediates this effect. Lateral ventricular (LV) injection of methysergide (40 microg) delayed the hypotensive, bradycardic, and sympathoinhibitory responses to blood withdrawal (1.26 ml/min) in conscious rats. The response was quantified, in part, as the blood volume withdrawal that produced a 40-mmHg fall in blood pressure. The delayed hypotensive response produced by methysergide (8.2 +/- 0.2 vs. 5.6 +/- 0.2 ml, P < 0.01) was reversed by the 5-hydroxytryptamine (HT)(1A) antagonist WAY-100635 (30 microg iv: 6.7 +/- 0.4 ml, P < 0. 01; 100 microg iv: 5.6 +/- 0.1 ml, P < 0.01). LV injection of the 5-HT(1A) agonist (+)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) also delayed the hypotensive (10 microg: 8.6 +/- 0.3, P < 0.01; 20 microg: 9.2 +/- 0.3 ml, P < 0.01), bradycardic, and sympathoinhibitory responses to hemorrhage. WAY-100635 (10 microg iv) completely reversed the effects of 8-OH-DPAT (20 microg: 5.4 +/- 0.3 ml). Neither selective blockade of 5-HT(2) receptors nor stimulation of 5-HT(1B/1D) receptors had any effect on hemorrhage responses. These data indicate that methysergide stimulates 5-HT(1A) receptors to delay the decompensatory responses to hemorrhage.

8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology

Animals

Bradycardia - prevention & control

Hemorrhage - complications

Hemorrhage - physiopathology

Hypotension - prevention & control

Male

Methysergide - administration & dosage

Methysergide - pharmacology

Piperazines - pharmacology

Pyridines - pharmacology

Rats

Rats, Sprague-Dawley

Receptors, Serotonin - drug effects

Receptors, Serotonin - physiology

Receptors, Serotonin, 5-HT1

Serotonin Antagonists - pharmacology

Serotonin Receptor Agonists - pharmacology

Details

Title: Subtitle: Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors
Creators: Karie E Scrogin - Department of Physiology and Pharmacology, The Oregon Health Sciences University, Portland, Oregon 97201, USA. kscrogi@luc.edu
Alan Kim Johnson
Virginia L Brooks
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.279(5), pp.R1776-R1786
DOI: 10.1152/ajpregu.2000.279.5.r1776
PMID: 11049861
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Grant note: HL-35872 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL-09545 / NHLBI NIH HHS
Language: English
Date published: 11/2000
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984214760002771

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