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Metronidazole-induced Encephalopathy
Journal article   Open access   Peer reviewed

Metronidazole-induced Encephalopathy

Htay Phyu, Michael B. Edmond and Takaaki Kobayashi
IDCases, Vol.18, pp.e00639-e00639
01/01/2019
DOI: 10.1016/j.idcr.2019.e00639
PMCID: PMC6804936
PMID: 31692663
url
https://doi.org/10.1016/j.idcr.2019.e00639View
Published (Version of record) Open Access

Abstract

Metronidazole is commonly used in the treatment of anaerobic infections. While neuropathy is known to be associated with metronidazole, encephalopathy has been rarely reported. We herein present a case of metronidazole-induced encephalopathy presenting as frequent falls and slurred speech. Magnetic resonance imaging of the brain demonstrated T2/FLAIR hyperintensity in the dentate nuclei bilaterally. Soon after the discontinuation of metronidazole, dysarthria and dysmetria resolved. Metronidazole-induced encephalopathy should be considered in patients presenting with new neurologic symptoms after the initiation of metronidazole. (C) 2019 The Authors. Published by Elsevier Ltd.
Infectious Diseases Life Sciences & Biomedicine Science & Technology

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