Journal article
Metronidazole-induced encephalopathy in a patient with cirrhosis
Radiology case reports, Vol.19(1), pp.126-129
01/01/2024
DOI: 10.1016/j.radcr.2023.10.001
PMCID: PMC10628797
PMID: 37941988
Abstract
Metronidazole is a commonly used antibiotic with anaerobic bacterial, protozoal, and microaerophilic bacterial coverage. Encephalopathy and peripheral neurotoxicity are rare but known adverse events with prolonged metronidazole use, which can be difficult to distinguish from other causes of delirium in acutely ill patients. Definitive diagnosis can be made by brain magnetic resonance imaging (MRI), which often reveals symmetric bilateral hypersignal demyelination lesions typically involving the dentate nuclei, splenium of the corpus collosum, midbrain, dorsal medulla, and pons. This case report describes a 72-year-old male presenting with altered mental status and neurological deficits after prolonged metronidazole use for bacteremia with spondylodiscitis, with full clinical and neuroradiological resolution upon appropriate diagnosis and drug cessation. Neuroradiologists play an indispensable role in recognizing this rare and poorly understood manifestation.
Details
- Title: Subtitle
- Metronidazole-induced encephalopathy in a patient with cirrhosis
- Creators
- Xinyu Ji - McGill UniversityKe Xuan Li - McGill UniversityLeonardo Furtado Freitas - McGill UniversityPhilippe Huot - McGill University
- Resource Type
- Journal article
- Publication Details
- Radiology case reports, Vol.19(1), pp.126-129
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.radcr.2023.10.001
- PMID
- 37941988
- PMCID
- PMC10628797
- ISSN
- 1930-0433
- eISSN
- 1930-0433
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Radiology
- Record Identifier
- 9984697628302771
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