Mice deficient for the CD40 ligand

Jianchao Xu; Teresa M Foy; Jon D Laman; Eileen A Elliott; Jonathan J Dunn; Thomas J Waldschmidt; Jennifer Elsemore; Randolph J Noelle; Richard A Flavell

doi:10.1016/1074-7613(94)90073-6

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Mice deficient for the CD40 ligand

Jianchao Xu, Teresa M Foy, Jon D Laman, Eileen A Elliott, Jonathan J Dunn, Thomas J Waldschmidt, Jennifer Elsemore, Randolph J Noelle and Richard A Flavell

Immunity (Cambridge, Mass.), Vol.1(5), pp.423-431

1994

DOI: 10.1016/1074-7613(94)90073-6

PMID: 7882172

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Abstract

To study the Potential roles of CD40L in immune responses, we generated CD40L-deficient mice by gene targeting. Similar to the effects of CD40L mutations in humans (hyper-IgM syndrome), CD40L-deficient mice have a decreased IgM response to thymus-dependent antigens, fail altogether to produce an antigen-specific IgG1 response following Immunization, yet respond normally to a T-Independent antigen, TNP-Ficoll. Moreover, these mice do not develop germinal centers in response to thymus-dependent antigens, suggesting an inability to develop memory B cell responses. Although CD40L-deficient mice have low levels of most circulating immunoglobulin isotypes, they do not exhibit the spontaneous hyper-IgM syndrome seen in humans, at least up to 12 weeks of age. In summary, our study confirms the important role of CD40-CD40L interactions in thymus-dependent humoral immune responses and germinal center formation.

Details

Title: Subtitle: Mice deficient for the CD40 ligand
Creators: Jianchao Xu - Section of Immunobiology, USA
Teresa M Foy - Department of Microbiology Dartmouth Medical School Lebanon, New Hampshire 03756, USA
Jon D Laman - Department of Microbiology Dartmouth Medical School Lebanon, New Hampshire 03756, USA
Eileen A Elliott - Alexion Pharmaceuticals, Incorporated New Haven, Connecticut 06511, USA
Jonathan J Dunn - Howard Hughes Medical Institute Yale University School of Medicine New Haven, Connecticut 06510, USA
Thomas J Waldschmidt - Department of Pathology University of Iowa Medical School Iowa City, Iowa 52242, USA
Jennifer Elsemore - Section of Immunobiology, USA
Randolph J Noelle - Howard Hughes Medical Institute Yale University School of Medicine New Haven, Connecticut 06510, USA
Richard A Flavell - Section of Immunobiology, USA
Resource Type: Journal article
Publication Details: Immunity (Cambridge, Mass.), Vol.1(5), pp.423-431
DOI: 10.1016/1074-7613(94)90073-6
PMID: 7882172
NLM abbreviation: Immunity
ISSN: 1074-7613
eISSN: 1097-4180
Publisher: Elsevier Inc
Language: English
Date published: 1994
Academic Unit: Pathology
Record Identifier: 9984047602402771

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