Journal article
Mice expressing P301S mutant human tau have deficits in interval timing
Behavioural brain research, Vol.432, pp.113967-113967
08/26/2022
DOI: 10.1016/j.bbr.2022.113967
PMCID: PMC9585768
PMID: 35718229
Abstract
Interval timing is a key executive process that involves estimating the duration of an interval over several seconds or minutes. Patients with Alzheimer’s disease (AD) have deficits in interval timing. Since temporal control of action is highly conserved across mammalian species, studying interval timing tasks in animal AD models may be relevant to human disease. Amyloid plaques and tau neurofibrillary tangles are hallmark features of AD. While rodent models of amyloid pathology are known to have interval timing impairments, to our knowledge, interval timing has not been studied in models of tauopathy. Here, we evaluate interval timing performance of P301S transgenic mice, a widely studied model of tauopathy that overexpresses human tau with the P301S mutation. We employed an interval timing task and found that P301S mice consistently underestimated temporal intervals compared to wild-type controls, responding early in anticipation of the target interval. Our study indicating timing deficits in a mouse tauopathy model could have relevance to human tauopathies such as AD.
•We examined interval timing behavior in mice expressing P301S mutant tau.•P301S mice responded earlier than littermate controls.•These data provide insight into animal models of tauopathy.
Details
- Title: Subtitle
- Mice expressing P301S mutant human tau have deficits in interval timing
- Creators
- Travis Larson - Duke University School of MedicineVaibhav Khandelwal - University of IowaMatthew A. Weber - University of IowaMariah R. Leidinger - University of IowaDavid K. Meyerholz - University of IowaNandakumar S. Narayanan - University of IowaQiang Zhang - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Behavioural brain research, Vol.432, pp.113967-113967
- DOI
- 10.1016/j.bbr.2022.113967
- PMID
- 35718229
- PMCID
- PMC9585768
- NLM abbreviation
- Behav Brain Res
- ISSN
- 0166-4328
- eISSN
- 1872-7549
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01MH116043, R01NS120987
- Language
- English
- Date published
- 08/26/2022
- Academic Unit
- Neurology; Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984267976802771
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