Journal article
MicroRNA-183 family conservation and ciliated neurosensory organ expression
Evolution & development, Vol.10(1), pp.106-113
2008
DOI: 10.1111/j.1525-142X.2007.00217.x
PMCID: PMC2637451
PMID: 18184361
Abstract
MicroRNAs (miRNAs) are an integral component of the metazoan genome and affect posttranscriptional repression of target messenger RNAs. The extreme phylogenetic conservation of certain miRNAs suggests their ancient origin and crucial function in conserved developmental processes. We demonstrate that highly conserved miRNA-183 orthologs exist in both deuterostomes and protostomes and their expression is predominant in ciliated ectodermal cells and organs. The miRNA-183 family members are expressed in vertebrate sensory hair cells, in innervated regions of invertebrate deuterostomes, and in sensilla of
Drosophila
and
C. elegans
. Thus, miRNA-183 family member expression is conserved in possibly homologous but morphologically distinct sensory cells and organs. The results suggest that miR-183 family members contribute specifically to neurosensory development or function, and that extant metazoan sensory organs are derived from cells that share genetic programs of common evolutionary origin.
Details
- Title: Subtitle
- MicroRNA-183 family conservation and ciliated neurosensory organ expression
- Creators
- Marsha L Pierce - Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USAMichael D Weston - Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USABernd Fritzsch - Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USAHarrison W Gabel - Department of Genetics, Harvard Medical School and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USAGary Ruvkun - Department of Genetics, Harvard Medical School and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USAGarrett A Soukup - Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
- Resource Type
- Journal article
- Publication Details
- Evolution & development, Vol.10(1), pp.106-113
- DOI
- 10.1111/j.1525-142X.2007.00217.x
- PMID
- 18184361
- PMCID
- PMC2637451
- NLM abbreviation
- Evol Dev
- ISSN
- 1520-541X
- eISSN
- 1525-142X
- Language
- English
- Date published
- 2008
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070516902771
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