Journal article
MicroRNA-31 is significantly elevated in both human endometrium and serum during the window of implantation: a potential biomarker for optimum receptivity
Biology of reproduction, Vol.91(1), pp.17-17
07/2014
DOI: 10.1095/biolreprod.113.116590
PMCID: PMC6322437
PMID: 24855107
Abstract
The window of implantation of human embryos into the endometrium spans Cycle Days 20-24 of the 28-day menstrual cycle. However, uterine receptivity may not be reliably replicated in infertile patients throughout this span. Thus, it is of importance to be able to determine optimal receptivity through a minimally invasive measure. We screened expression of a number of candidate micro-RNAs (miRNAs) in endometrial tissues and serum collected from a panel of fertile women during both the proliferative phase and the secretory phase of a normal menstrual cycle. We found that several miRNAs were significantly elevated in endometrial tissues in the secretory phase versus the proliferative phase. One of these, miR-31, was found to be not only detectable in serum samples but also significantly elevated in the secretory phase versus the proliferative phase. MiR-31 is known to target several immunomodulatory factors, such as FOXP3 and CXCL12. We find that both of these factors are significantly downregulated in endometrial tissues during the secretory phase. Our data suggest that miR-31 is a potential biomarker for optimal endometrial receptivity, possibly operating through an immunosuppressive mechanism.
Details
- Title: Subtitle
- MicroRNA-31 is significantly elevated in both human endometrium and serum during the window of implantation: a potential biomarker for optimum receptivity
- Creators
- Jessica D K Kresowik - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IowaEric J Devor - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IowaBradley J Van Voorhis - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IowaKimberly K Leslie - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa Kimberly-leslie@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Biology of reproduction, Vol.91(1), pp.17-17
- DOI
- 10.1095/biolreprod.113.116590
- PMID
- 24855107
- PMCID
- PMC6322437
- NLM abbreviation
- Biol Reprod
- ISSN
- 0006-3363
- eISSN
- 1529-7268
- Publisher
- United States
- Grant note
- R01 CA099908 / NCI NIH HHS
- Language
- English
- Date published
- 07/2014
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983930404902771
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