MicroRNA function in craniofacial bone formation, regeneration and repair

Liu Hong; Hongli Sun; Brad A. Amendt

doi:10.1016/j.bone.2020.115789

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MicroRNA function in craniofacial bone formation, regeneration and repair

Journal article

Peer reviewed

MicroRNA function in craniofacial bone formation, regeneration and repair

Liu Hong, Hongli Sun and Brad A. Amendt

Bone (New York, N.Y.), Vol.144, pp.115789-115789

03/2021

DOI: 10.1016/j.bone.2020.115789

PMCID: PMC7869528

PMID: 33309989

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https://www.ncbi.nlm.nih.gov/pmc/articles/7869528View

Open Access

Abstract

Bone formation in the craniofacial complex is regulated by cranial neural crest (CNC) and mesoderm-derived cells. Different elements of the developing skull, face, mandible, maxilla (jaws) and nasal bones are regulated by an array of transcription factors, signaling molecules and microRNAs (miRs). miRs are molecular modulators of these factors and act to restrict their expression in a temporal-spatial mechanism. miRs control the different genetic pathways that form the craniofacial complex. By understanding how miRs function in vivo during development they can be adapted to regenerate and repair craniofacial genetic anomalies as well as bone diseases and defects due to traumatic injuries. This review will highlight some of the new miR technologies and functions that form new bone or inhibit bone regeneration. [Display omitted] •MicroRNAs regulate genetic pathways that form bone and inhibit bone regeneration.•New microRNA inhibition technology (PMIS) proven in transgenic mice models•MicroRNAs regulate bone formation, inflammation, osteoporosis and periodontitis.•New microRNA inhibition technology (PMIS) more efficacious than oligonucleotides•MicroRNA gene therapy approaches are compared to stem cell-based scaffolds.

Bone development

Bone regeneration

Bone repair

microRNA inhibitor system (PMIS)

microRNA mouse models

microRNA therapeutic

Details

Title: Subtitle: MicroRNA function in craniofacial bone formation, regeneration and repair
Creators: Liu Hong - University of Iowa
Hongli Sun - University of Iowa
Brad A. Amendt - University of Iowa
Resource Type: Journal article
Publication Details: Bone (New York, N.Y.), Vol.144, pp.115789-115789
DOI: 10.1016/j.bone.2020.115789
PMID: 33309989
PMCID: PMC7869528
NLM abbreviation: Bone
ISSN: 8756-3282
eISSN: 1873-2763
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research
Language: English
Date published: 03/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthodontics; Anatomy and Cell Biology; Prosthodontics; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery; Dental Research
Record Identifier: 9984284451102771

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