MicroRNA regulation of BAG3

Madhu V Singh; Karthik Dhanabalan; Joseph Verry; Ayotunde O Dokun

doi:10.1177/15353702211066908

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MicroRNA regulation of BAG3

Madhu V Singh, Karthik Dhanabalan, Joseph Verry and Ayotunde O Dokun

Experimental biology and medicine (Maywood, N.J.), Vol.247(8), pp.617-623

04/2022

DOI: 10.1177/15353702211066908

PMCID: PMC9039493

PMID: 35037515

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039493View

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Abstract

B-cell lymphoma 2 (Bcl-2)-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that modulates major biological processes, including apoptosis, autophagy, and development to promote cellular adaptive responses to stress stimuli. Although BAG3 is constitutively expressed in several cell types, its expression is also inducible and is regulated by microRNAs (miRNAs). miRNAs are small non-coding RNAs that mostly bind to the 3'-UTR (untranslated region) of mRNAs to inhibit their translation or to promote their degradation. miRNAs can potentially regulate over 50% of the protein-coding genes in a cell and therefore are involved in the regulation of all major functions, including cell differentiation, growth, proliferation, apoptosis, and autophagy. Dysregulation of miRNA expression is associated with pathogenesis of numerous diseases, including peripheral artery disease (PAD). BAG3 plays a critical role in regulating the response of skeletal muscle cells to ischemia by its ability to regulate autophagy. However, the biological role of miRNAs in the regulation of BAG3 in biological processes has only been elucidated recently. In this review, we discuss how miRNA may play a key role in regulating BAG3 expression under normal and pathological conditions.

Adaptor Proteins, Signal Transducing - genetics

Adaptor Proteins, Signal Transducing - metabolism

Apoptosis

Apoptosis Regulatory Proteins - genetics

Apoptosis Regulatory Proteins - metabolism

Autophagy - genetics

MicroRNAs - genetics

Details

Title: Subtitle: MicroRNA regulation of BAG3
Creators: Madhu V Singh - University of Iowa
Karthik Dhanabalan - University of Iowa
Joseph Verry - University of Iowa
Ayotunde O Dokun - University of Iowa
Resource Type: Journal article
Publication Details: Experimental biology and medicine (Maywood, N.J.), Vol.247(8), pp.617-623
DOI: 10.1177/15353702211066908
PMID: 35037515
PMCID: PMC9039493
ISSN: 1535-3702
eISSN: 1535-3699
Grant note: R01 HL130399 / NHLBI NIH HHS
Language: English
Date published: 04/2022
Academic Unit: Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984297512302771

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