Journal article
MicroRNA-targeted therapeutics for lung cancer treatment
Expert opinion on drug discovery, Vol.12(2), pp.141-157
02/01/2017
DOI: 10.1080/17460441.2017.1263298
PMID: 27866431
Abstract
Introduction: Lung cancer is one of the leading causes of cancer-related mortality worldwide. MicroRNAs (miRNAs) are endogenous non-coding small RNAs that repress the expression of a broad array of target genes. Many efforts have been made to therapeutically target miRNAs in cancer treatments using miRNA mimics and miRNA antagonists.
Areas covered: This article summarizes the recent findings with the role of miRNAs in lung cancer, and discusses the potential and challenges of developing miRNA-targeted therapeutics in this dreadful disease.
Expert opinion: The development of miRNA-targeted therapeutics has become an important anti-cancer strategy. Results from both preclinical and clinical trials of microRNA replacement therapy have shown some promise in cancer treatment. However, some obstacles, including drug delivery, specificity, off-target effect, toxicity mediation, immunological activation and dosage determination should be addressed. Several delivery strategies have been employed, including naked oligonucleotides, liposomes, aptamer-conjugates, nanoparticles and viral vectors. However, delivery remains a main challenge in miRNA-targeting therapeutics. Furthermore, immune-related serious adverse events are also a concern, which indicates the complexity of miRNA-based therapy in clinical settings.
Details
- Title: Subtitle
- MicroRNA-targeted therapeutics for lung cancer treatment
- Creators
- Jing Xue - College of Life Science, Ningxia UniversityJiali Yang - Center of Laboratory Medicine, General Hospital of Ningxia Medical UniversityMeihui Luo - Center of Laboratory Medicine, General Hospital of Ningxia Medical UniversityWilliam C Cho - Department of Clinical Oncology, Queen Elizabeth HospitalXiaoming Liu - Human Stem Cell Institute, General Hospital of Ningxia Medical University
- Resource Type
- Journal article
- Publication Details
- Expert opinion on drug discovery, Vol.12(2), pp.141-157
- Publisher
- Taylor & Francis
- DOI
- 10.1080/17460441.2017.1263298
- PMID
- 27866431
- ISSN
- 1746-0441
- eISSN
- 1746-045X
- Grant note
- 31472191 / National Natural Science Foundation of China (10.13039/501100001809)
- Language
- English
- Date published
- 02/01/2017
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984025335702771
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