Journal article
MicroRNA‐based risk scoring system to identify early‐stage oral squamous cell carcinoma patients at high‐risk for cancer‐specific mortality
Head & neck, Vol.42(8), pp.1699-1712
08/2020
DOI: 10.1002/hed.26089
PMCID: PMC7369212
PMID: 31981257
Abstract
Background
For early‐stage oral squamous cell carcinoma (OSCC), there is no existing risk‐stratification modality beyond conventional TNM staging system to identify patients at high risk for cancer‐specific mortality.
Methods
A total of 568 early‐stage OSCC patients who had surgery only and also with available 5‐year clinical outcomes data were identified. Signature microRNAs (miRNAs) were discovered using deep sequencing analysis and validated by qRT‐PCR. The final 5‐plex prognostic marker panel was utilized to generate a cancer‐specific mortality risk score using the multivariate Cox regression analyses. The prognostic markers were validated in the internal and external validation cohorts.
Results
The risk score from the 5‐plex marker panel consisting of miRNAs‐127‐3p, 4736, 655‐3p, TNM stage and histologic grading stratified patients into four risk categories. Compared to the low‐risk group, the high‐risk group had 23‐fold increased mortality risk (hazard ratio 23, 95% confidence interval 13‐42), with a median time‐to‐recurrence of 6 months and time‐to‐death of 11 months (vs >60 months for each among low‐risk patient; p < .001).
Conclusion
The miRNA‐based 5‐plex marker panel driven mortality risk score formula provides clinically practical and reliable measures to assess the prognosis of patients assigned to an early‐stage OSCC.
Details
- Title: Subtitle
- MicroRNA‐based risk scoring system to identify early‐stage oral squamous cell carcinoma patients at high‐risk for cancer‐specific mortality
- Creators
- Angela J Yoon - Columbia University College of Dental Medicine, Columbia University Irving Medical CenterShuang Wang - Columbia University Mailman School of Public HealthDavid I Kutler - Weill Cornell Medical CollegeRichard D Carvajal - Columbia University Irving Medical CenterElizabeth Philipone - Columbia University College of Dental Medicine, Columbia University Irving Medical CenterTian Wang - Columbia University Mailman School of Public HealthScott M Peters - Columbia University College of Dental Medicine, Columbia University Irving Medical CenterDominic LaRoche - HTG Molecular Diagnostic, IncBrenda Y Hernandez - Hawaii Tumor Registry, University of Hawaii Cancer CenterBradley D McDowell - Holden Comprehensive Cancer Center, University of IowaClaire R Stewart - Weill Cornell Medical CollegeFatemeh Momen‐Heravi - Columbia University College of Dental MedicineRegina M Santella - Columbia University Mailman School of Public Health
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.42(8), pp.1699-1712
- DOI
- 10.1002/hed.26089
- PMID
- 31981257
- PMCID
- PMC7369212
- NLM abbreviation
- Head Neck
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Publisher
- John Wiley & Sons, Inc; Hoboken, USA
- Number of pages
- 14
- Grant note
- NIH/NIDCR (R01DE026801) NIH/NIEHS (P30ES009089) NIH/NCI (P30CA013696; P30CA071789; P30CA086862)
- Language
- English
- Date published
- 08/2020
- Academic Unit
- Holden Comprehensive Cancer Center
- Record Identifier
- 9984066351802771
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