Journal article
MicroRNAs and Polycystic Kidney Disease
Drug discovery today. Disease models, Vol.10(3), pp.e137-e143
2013
DOI: 10.1016/j.ddmod.2013.10.001
PMCID: PMC4159181
PMID: 25221607
Abstract
Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to retard cyst growth. Here, we review current evidence implicating two groups of miRNAs - the miR-17~92 cluster and miR-200s - in the pathogenesis of PKD. We present a new hypothesis for cyst growth involving miRNAs and regulation of PKD gene dosage. We propose that manipulating miRNA function in an attempt to normalize PKD gene dosage represents a novel therapeutic strategy in PKD.
Details
- Title: Subtitle
- MicroRNAs and Polycystic Kidney Disease
- Creators
- Lama Noureddine - Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USASachin Hajarnis - Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USAVishal Patel - Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
- Resource Type
- Journal article
- Publication Details
- Drug discovery today. Disease models, Vol.10(3), pp.e137-e143
- DOI
- 10.1016/j.ddmod.2013.10.001
- PMID
- 25221607
- PMCID
- PMC4159181
- NLM abbreviation
- Drug Discov Today Dis Models
- ISSN
- 1740-6757
- eISSN
- 1740-6757
- Grant note
- R03 DK099568 / NIDDK NIH HHS P30 DK079328 / NIDDK NIH HHS T32 DK007257 / NIDDK NIH HHS K08 DK084311 / NIDDK NIH HHS
- Language
- English
- Date published
- 2013
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094308802771
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