Journal article
MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
Cardiovascular diabetology, Vol.19(1), pp.136-136
09/09/2020
DOI: 10.1186/s12933-020-01107-3
PMCID: PMC7488343
PMID: 32907629
Abstract
The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of normal endothelium, leading to endothelial dysfunction which predisposes the patient to cardiovascular diseases. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that play important roles in a variety of cellular processes such as differentiation, proliferation, apoptosis, and stress response; their alteration contributes to the development of many pathologies including obesity. Mediators of obesity-induced endothelial dysfunction include altered endothelial nitric oxide synthase (eNOS), Sirtuin 1 (SIRT1), oxidative stress, autophagy machinery and endoplasmic reticulum (ER) stress. All of these factors have been shown to be either directly or indirectly caused by gene regulatory mechanisms of miRNAs. In this review, we aim to provide a comprehensive description of the therapeutic potential of miRNAs to treat obesity-induced endothelial dysfunction. This may lead to the identification of new targets for interventions that may prevent or delay the development of obesity-related cardiovascular disease.
Details
- Title: Subtitle
- MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
- Creators
- Karima Ait-Aissa - Roy J. and Lucille A. Carver College of MedicineQuynh My Nguyen - University of MontanaMohanad Gabani - Roy J. and Lucille A. Carver College of MedicineAdam Kassan - West Coast UniversitySantosh Kumar - Roy J. and Lucille A. Carver College of MedicineSoo-Kyoung Choi - Seoul, South KoreaAlexis A. Gonzalez - University of ValparaísoTahsin Khataei - Roy J. and Lucille A. Carver College of MedicineAmal M. Sahyoun - McGill UniversityCheng Chen - Shanghai Jiao Tong UniversityModar Kassan - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Cardiovascular diabetology, Vol.19(1), pp.136-136
- Publisher
- BioMed Central
- DOI
- 10.1186/s12933-020-01107-3
- PMID
- 32907629
- PMCID
- PMC7488343
- ISSN
- 1475-2840
- eISSN
- 1475-2840
- Grant note
- AHA-18CDA34030155 / ;
- Language
- English
- Date published
- 09/09/2020
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359695402771
Metrics
16 Record Views