Journal article
MicroRNAs as biomarkers of resilience or vulnerability to stress
Neuroscience, Vol.305, pp.36-48
10/01/2015
DOI: 10.1016/j.neuroscience.2015.07.045
PMID: 26208845
Abstract
•MicroRNAs in blood are associated with future vulnerability or ongoing resilience.•MicroRNAs in the medial prefrontal cortex are associated with vulnerability.•MicroRNAs in the basolateral amygdala do not differentiate vulnerability from resilience.
Identifying novel biomarkers of resilience or vulnerability to stress could provide valuable information for the prevention and treatment of stress-related psychiatric disorders. To investigate the utility of blood microRNAs as biomarkers of resilience or vulnerability to stress, microRNAs were assessed before and after 7days of chronic social defeat in rats. Additionally, microRNA profiles of two important stress-regulatory brain regions, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA), were assessed. Rats that displayed vulnerability to subsequent chronic stress exhibited reductions in circulating miR-24-2-5p, miR-27a-3p, miR-30e-5p, miR-3590-3p, miR-362-3p, and miR-532-5p levels. In contrast, rats that became resilient to stress displayed reduced levels of miR-139-5p, miR-28-3p, miR-326-3p, and miR-99b-5p compared to controls. In the mPFC, miR-126a-3p and miR-708-5p levels were higher in vulnerability compared to resilient rats. In the BLA, 77 microRNAs were significantly altered by stress but none were significantly different between resilient and vulnerable animals. These results provide proof-of-principle that assessment of circulating microRNAs is useful in identifying individuals who are vulnerable to the effects of future stress or individuals who have become resilient to the effects of stress. Furthermore, these data suggest that microRNAs in the mPFC but not in the BLA are regulators of resilience/vulnerability to stress.
Details
- Title: Subtitle
- MicroRNAs as biomarkers of resilience or vulnerability to stress
- Creators
- R.J Chen - Department of Anesthesiology, Children’s Hospital of Philadelphia, United StatesG Kelly - Department of Anesthesiology, Children’s Hospital of Philadelphia, United StatesA Sengupta - Department of Anesthesiology, Children’s Hospital of Philadelphia, United StatesW Heydendael - Department of Anesthesiology, Children’s Hospital of Philadelphia, United StatesB Nicholas - Department of Anesthesiology, Children’s Hospital of Philadelphia, United StatesS Beltrami - Department of Anesthesiology, Children’s Hospital of Philadelphia, United StatesS Luz - Department of Anesthesiology, Children’s Hospital of Philadelphia, United StatesL Peixoto - Department of Biology, University of Pennsylvania, United StatesT Abel - Department of Biology, University of Pennsylvania, United StatesS Bhatnagar - Department of Anesthesiology, Children’s Hospital of Philadelphia, United States
- Resource Type
- Journal article
- Publication Details
- Neuroscience, Vol.305, pp.36-48
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.neuroscience.2015.07.045
- PMID
- 26208845
- ISSN
- 0306-4522
- eISSN
- 1873-7544
- Grant note
- DOI: 10.13039/100000185, name: DARPA; DOI: 10.13039/100000183, name: US Army Research Office, award: W911NF1010093
- Language
- English
- Date published
- 10/01/2015
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065834002771
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