Journal article
MicroRNAs in benign and malignant hematopoiesis
Archives of pathology & laboratory medicine (1976), Vol.134(9), pp.1276-1281
09/01/2010
DOI: 10.1043/2009-0178-RS.1
PMID: 20807046
Abstract
MicroRNAs (miRNAs) are a family of 19- to 24-nucleotide noncoding RNAs that regulate messenger RNA function at the posttranscriptional and translational level. Recent literature demonstrates a significant role of miRNAs in normal and malignant hematopoiesis. Specific miRNAs have been shown to regulate each step of hematopoiesis starting at the level of multipotent progenitors through terminal stages of myeloid and lymphoid differentiation. Similarly, individual miRNAs and miRNA signatures have been associated with specific hematologic malignancies. There is accumulating evidence that miRNAs can be used for diagnostic, prognostic, and therapeutic purposes. This review highlights the current status of knowledge on miRNA in normal and malignant hematopoiesis.
Details
- Title: Subtitle
- MicroRNAs in benign and malignant hematopoiesis
- Creators
- Sharathkumar Bhagavathi - University of Iowa, PathologyMagdalena Czader
- Resource Type
- Journal article
- Publication Details
- Archives of pathology & laboratory medicine (1976), Vol.134(9), pp.1276-1281
- DOI
- 10.1043/2009-0178-RS.1
- PMID
- 20807046
- eISSN
- 1543-2165
- Language
- English
- Date published
- 09/01/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984046910702771
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