Microbial Communities in Gynecological Cancers and Their Association with Tumor Somatic Variation

Jesus Gonzalez-Bosquet; Megan E. McDonald; David P. Bender; Brian J. Smith; Kimberly K. Leslie; Michael J. Goodheart; Eric J. Devor

doi:10.3390/cancers15133316

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Microbial Communities in Gynecological Cancers and Their Association with Tumor Somatic Variation

Journal article

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Microbial Communities in Gynecological Cancers and Their Association with Tumor Somatic Variation

Jesus Gonzalez-Bosquet, Megan E. McDonald, David P. Bender, Brian J. Smith, Kimberly K. Leslie, Michael J. Goodheart and Eric J. Devor

Cancers, Vol.15(13), p.3316

06/23/2023

DOI: 10.3390/cancers15133316

PMCID: PMC10340580

PMID: 37444425

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https://doi.org/10.3390/cancers15133316View

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Abstract

There are strong correlations between the microbiome and human disease, including cancer. However, very little is known about potential mechanisms associated with malignant transformation in microbiome-associated gynecological cancer, except for HPV-induced cervical cancer. Our hypothesis is that differences in bacterial communities in upper genital tract epithelium may lead to selection of specific genomic variation at the cellular level of these tissues that may predispose to their malignant transformation. We first assessed differences in the taxonomic composition of microbial communities and genomic variation between gynecologic cancers and normal samples. Then, we performed a correlation analysis to assess whether differences in microbial communities selected for specific single nucleotide variation (SNV) between normal and gynecological cancers. We validated these results in independent datasets. This is a retrospective nested case-control study that used clinical and genomic information to perform all analyses. Our present study confirms a changing landscape in microbial communities as we progress into the upper genital tract, with more diversity in lower levels of the tract. Some of the different genomic variations between cancer and controls strongly correlated with the changing microbial communities. Pathway analyses including these correlated genes may help understand the basis for how changing bacterial landscapes may lead to these cancers. However, one of the most important implications of our findings is the possibility of cancer prevention in women at risk by detecting altered bacterial communities in the upper genital tract epithelium.

Details

Title: Subtitle: Microbial Communities in Gynecological Cancers and Their Association with Tumor Somatic Variation
Creators: Jesus Gonzalez-Bosquet - University of Iowa Hospitals and Clinics
Megan E. McDonald - University of Iowa
David P. Bender - University of Iowa
Brian J. Smith - University of Iowa
Kimberly K. Leslie - University of New Mexico
Michael J. Goodheart - University of Iowa
Eric J. Devor - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Cancers, Vol.15(13), p.3316
DOI: 10.3390/cancers15133316
PMID: 37444425
PMCID: PMC10340580
NLM abbreviation: Cancers (Basel)
ISSN: 2072-6694
eISSN: 2072-6694
Grant note: DOI: 10.13039/100000002, name: NIH, award: R01 CA99908, R01 CA184101; name: Department of Obstetrics and Gynecology at the University of Iowa; name: American Association of Obstetricians and Gynecologists Foundation (AAOGF) Bridge Funding Award
Language: English
Date published: 06/23/2023
Academic Unit: Biostatistics; Obstetrics and Gynecology; Holden Comprehensive Cancer Center
Record Identifier: 9984442224302771

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