Journal article
Microbial NAD metabolism: lessons from comparative genomics
Microbiology and molecular biology reviews : MMBR, Vol.73(3), pp.529-541
09/2009
DOI: 10.1128/MMBR.00042-08
PMCID: PMC2738131
PMID: 19721089
Abstract
NAD is a coenzyme for redox reactions and a substrate of NAD-consuming enzymes, including ADP-ribose transferases, Sir2-related protein lysine deacetylases, and bacterial DNA ligases. Microorganisms that synthesize NAD from as few as one to as many as five of the six identified biosynthetic precursors have been identified. De novo NAD synthesis from aspartate or tryptophan is neither universal nor strictly aerobic. Salvage NAD synthesis from nicotinamide, nicotinic acid, nicotinamide riboside, and nicotinic acid riboside occurs via modules of different genes. Nicotinamide salvage genes nadV and pncA, found in distinct bacteria, appear to have spread throughout the tree of life via horizontal gene transfer. Biochemical, genetic, and genomic analyses have advanced to the point at which the precursors and pathways utilized by a microorganism can be predicted. Challenges remain in dissecting regulation of pathways.
Details
- Title: Subtitle
- Microbial NAD metabolism: lessons from comparative genomics
- Creators
- Francesca Gazzaniga - Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USARebecca StebbinsSheila Z ChangMark A McPeekCharles Brenner
- Resource Type
- Journal article
- Publication Details
- Microbiology and molecular biology reviews : MMBR, Vol.73(3), pp.529-541
- Publisher
- United States
- DOI
- 10.1128/MMBR.00042-08
- PMID
- 19721089
- PMCID
- PMC2738131
- ISSN
- 1092-2172
- eISSN
- 1098-5557
- Language
- English
- Date published
- 09/2009
- Academic Unit
- Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9983788431102771
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