Journal article
Microbial biotransformations of bile acids as detected by electrospray mass spectrometry
Advances in nutrition (Bethesda, Md.), Vol.4(1), pp.29-35
01/01/2013
DOI: 10.3945/an.112.003061
PMID: 23319120
Abstract
Many current experiments investigating the effects of diet, dietary supplements, and pre- and probiotics on the intestinal environments do not take into consideration the potential for using bile salts as markers of environmental change. Intestinal bacteria in vertebrates can metabolize bile acids into a number of different structures, with deamidation, hydroxyl group oxidation, and hydroxyl group elimination. Fecal bile acids are readily available to sample and contain a considerable structural complexity that directly relates to intestinal morphology, bile acid residence time in the intestine, and the species of microbial forms in the intestinal tract. Here we offer a classification scheme that can serve as an initial guide to interpret the different bile acid patterns expressed in vertebrate feces.
Details
- Title: Subtitle
- Microbial biotransformations of bile acids as detected by electrospray mass spectrometry
- Creators
- Lee R Hagey - Department of Medicine, University of California at San Diego, USA. lhagey@ucsd.eduMatthew D Krasowski
- Resource Type
- Journal article
- Publication Details
- Advances in nutrition (Bethesda, Md.), Vol.4(1), pp.29-35
- Publisher
- United States
- DOI
- 10.3945/an.112.003061
- PMID
- 23319120
- ISSN
- 2161-8313
- eISSN
- 2156-5376
- Language
- English
- Date published
- 01/01/2013
- Academic Unit
- Pathology
- Record Identifier
- 9984047679902771
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