Journal article
Microbial dormancy in batch cultures as a function of substrate-dependent mortality
Journal of theoretical biology, Vol.293, pp.34-40
01/21/2012
DOI: 10.1016/j.jtbi.2011.10.003
PMID: 22004996
Abstract
We present models and computational studies of dormancy in batch cultures to try to understand the relationship between reculturing time and death penalty for low substrate and the relative advantage of fast versus slow reawakening on the part of the bacteria. We find that the advantage goes to the faster waker for shorter reculturing times and lower mortality under low substrate, and moves to the slower waker as reculturing times and death penalty increase. The advantage returns again to the fast waker for very high death penalties. We use an explicit, continuous structure variable to represent dormancy so as to allow for flexibility in substrate usage on the part of dormant cells, and for a more mechanistic representation of the reawakening process. ► We study the relative advantage of fast versus slow reawakening in bacteria. ► The faster waker wins for shorter reculturing times and lower mortality. ► The slow waker wins as reculturing times and death penalty increase.
Details
- Title: Subtitle
- Microbial dormancy in batch cultures as a function of substrate-dependent mortality
- Creators
- Bruce P Ayati - Department of Mathematics and Program in Applied Mathematical & Computational Sciences, University of Iowa, Iowa City, IA 52242-1419, United States
- Resource Type
- Journal article
- Publication Details
- Journal of theoretical biology, Vol.293, pp.34-40
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jtbi.2011.10.003
- PMID
- 22004996
- ISSN
- 0022-5193
- eISSN
- 1095-8541
- Grant note
- name: National Science Foundation, award: DMS-0914514
- Language
- English
- Date published
- 01/21/2012
- Academic Unit
- Orthopedics and Rehabilitation; Mathematics
- Record Identifier
- 9983985834402771
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