Journal article
Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis
Expert Review of Neurotherapeutics, Vol.19(1), pp.45-53
01/02/2019
DOI: 10.1080/14737175.2019.1555473
PMCID: PMC6548683
PMID: 30513004
Abstract
Introduction: The gut microbiome helps to maintain a person's healthy state while perturbations in its function often leading to the development of inflammatory diseases including multiple sclerosis (MS). Consequently, gut-commensals which restore homeostasis have the potential to become novel therapeutic options for treating MS. MS patients have presented gut dysbiosis with a reduction in bacteria belonging to the Prevotella genus. Notably, increased levels of Prevotella are observed when disease-modifying therapies are used. Additionally, Prevotella histicola, an anaerobic bacterium derived from the human, can suppress disease in mice with experimental autoimmune encephalomyelitis, a preclinical MS model. Areas covered: This review compares MS microbiome studies from different geographical regions to identify common gut bacteria. Literature on the potential use of P. histicola as a therapy for MS and the next steps for developing microbial monotherapies in MS is also discussed. Expert commentary: Recent findings presenting an inverse correlation between Prevotella and MS disease severity and ability of P. histicola to suppress disease in preclinical models suggest that P. histicola might provide an additional treatment option for MS patients. However, rigorous testing in well-designed control trials should be performed to determine the safety and efficacy P. histicola in MS patients.
Details
- Title: Subtitle
- Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis
- Creators
- Ashutosh K Mangalam - Department of Pathology, Carver College of Medicine University of IowaJoseph Murray - Division of Gastroenterology and Hepatology, Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Expert Review of Neurotherapeutics, Vol.19(1), pp.45-53
- DOI
- 10.1080/14737175.2019.1555473
- PMID
- 30513004
- PMCID
- PMC6548683
- NLM abbreviation
- Expert Rev Neurother
- ISSN
- 1473-7175
- eISSN
- 1744-8360
- Publisher
- Taylor & Francis
- Grant note
- RG 5138A1/1 / National Multiple Sclerosis Society Minnesota Chapter (10.13039/100001770) 1R01AI137075 / National Institute of Allergy and Infectious Diseases (10.13039/100000060)
- Language
- English
- Date published
- 01/02/2019
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9983905645502771
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