Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease

Farrah C Phillips; Prajwal Gurung; Thirumala-Devi Kanneganti

doi:10.1080/19490976.2016.1182289

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Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease

Journal article

Open access

Peer reviewed

Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease

Farrah C Phillips, Prajwal Gurung and Thirumala-Devi Kanneganti

Gut microbes, Vol.7(4), pp.334-341

07/03/2016

DOI: 10.1080/19490976.2016.1182289

PMCID: PMC4988461

PMID: 27148834

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Abstract

A leucine-to-proline missense mutation at residue 98 in the proline-serine-threonine phosphatase interacting protein 2 (Pstpip2) gene leads to autoinflammatory disease that is characterized by splenomegaly, necrosis, and spontaneous development of osteomyelitis in mice (Pstpip2 cmo ). Disease progression in these mice resembles that of chronic recurrent multifocal osteomyelitis in humans. Our group and others have shown that disease progression in Pstpip2 cmo mice is mediated by the cytokine IL-1β, independently of inflammasomes or IL-1α. Our recent publication highlighted herein establishes that diet-induced changes in intestinal microbiota provide protection against the development of osteomyelitis in Pstpip2 cmo mice. Moreover, the proteases caspase-1 and caspase-8 have redundant roles in cleaving IL-1β and promoting disease. This addendum reviews the current literature on the Pstpip2 cmo murine disease model and the clinical significance of the role of PSTPIP2 in regulating autoinflammatory osteomyelitis, which is mediated by innate components of immune cells.

microbiota

osteomyelitis

high-fat diet

autoinflammatory

Pstpip2

IL-1beta

neutrophil

caspase

Details

Title: Subtitle: Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease
Creators: Farrah C Phillips - Department of Immunology, St. Jude Children's Research Hospital
Prajwal Gurung - Department of Immunology, St. Jude Children's Research Hospital
Thirumala-Devi Kanneganti - Department of Immunology, St. Jude Children's Research Hospital
Resource Type: Journal article
Publication Details: Gut microbes, Vol.7(4), pp.334-341
Publisher: Taylor & Francis
DOI: 10.1080/19490976.2016.1182289
PMID: 27148834
PMCID: PMC4988461
ISSN: 1949-0976
eISSN: 1949-0984
Language: English
Date published: 07/03/2016
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9984094643302771

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