Journal article
Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice
Scientific reports, Vol.10(1), pp.10065-10065
06/22/2020
DOI: 10.1038/s41598-020-66786-0
PMCID: PMC7308358
PMID: 32572127
Abstract
An impaired decline in blood pressure at rest is typical in people with diabetes, reflects endothelial dysfunction, and increases the risk of end-organ damage. Here we report that microRNA-204 (miR-204) promotes endothelial dysfunction and impairment in blood pressure decline during inactivity. We show that db/db mice overexpress miR-204 in the aorta, and its absence rescues endothelial dysfunction and impaired blood pressure decline during inactivity despite obesity. The vascular miR-204 is sensitive to microbiota, and microbial suppression reversibly decreases aortic miR-204 and improves endothelial function, while the endothelial function of mice lacking miR-204 remained indifferent to the microbial alterations. We also show that the circulating miR-122 regulates vascular miR-204 as miR-122 inhibition decreases miR-204 in endothelial cells and aorta. This study establishes that miR-204 impairs endothelial function, promotes impairment in blood pressure decline during rest, and opens avenues for miR-204 inhibition strategies against vascular dysfunction.
Details
- Title: Subtitle
- Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice
- Creators
- Ravinder Reddy Gaddam - Roy J. and Lucille A. Carver College of MedicineVeronica Peotta Jacobsen - Roy J. and Lucille A. Carver College of MedicineYoung-Rae Kim - Roy J. and Lucille A. Carver College of MedicineMohanad Gabani - Roy J. and Lucille A. Carver College of MedicineJulia S. Jacobs - Roy J. and Lucille A. Carver College of MedicineKarishma Dhuri - University of ConnecticutSantosh Kumar - Roy J. and Lucille A. Carver College of MedicineModar Kassan - Roy J. and Lucille A. Carver College of MedicineQiuxia Li - Roy J. and Lucille A. Carver College of MedicineRaman Bahal - University of ConnecticutRobert Roghair - Roy J. and Lucille A. Carver College of MedicineKaikobad Irani - Roy J. and Lucille A. Carver College of MedicineAjit Vikram - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.10(1), pp.10065-10065
- DOI
- 10.1038/s41598-020-66786-0
- PMID
- 32572127
- PMCID
- PMC7308358
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- Nature Publishing Group UK
- Language
- English
- Date published
- 06/22/2020
- Academic Unit
- Stead Family Department of Pediatrics; Cardiovascular Medicine; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Neonatology; Internal Medicine
- Record Identifier
- 9984313094502771
Metrics
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