Journal article
Microcephaly and arthrogryposis multiplex congenita: The full-blown CNS spectrum in newborns with ZIKV infection
Journal of the neurological sciences, Vol.372, pp.73-74
01/15/2017
DOI: 10.1016/j.jns.2016.11.030
PMID: 28017252
Abstract
The recent alarming statements concerning the newborn ZIKV-induced microcephaly epidemics in the Northeast of Brazil, released by the Brazilian Ministry of Health, as well as important international health agencies, such as the World Health Organization and the Pan American Health Organization, raised many "why and how" questions so far, that will hopefully be scientifically answered, as more researches in that regard come up in the long term. In this paper, we describe another potentially ZIKV-induced central nervous system and musculoskeletal disorder that has accompanied microcephaly in these children: atrhogryposis multiplex congenita. The goal is to bring up some hypotheses for possible underlying molecular mechanisms based on published data taken from animal models, such as ovine and cattle, which once infected by other types of arboviroses and viruses that also belong to the Flaviviridae family, presented, too, with the full-blown CNS spectrum of malformations at birth.
Details
- Title: Subtitle
- Microcephaly and arthrogryposis multiplex congenita: The full-blown CNS spectrum in newborns with ZIKV infection
- Creators
- Marcio Leyser - Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil. Electronic address: marcioley@icloud.comAlexandre Fernandes - Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, BrazilPamela Passos - Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, BrazilCamila Pupe - Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, BrazilAndre Pc Matta - Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, BrazilMarcio Moacyr Vasconcelos - Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, BrazilOsvaldo Jm Nascimento - Federal Fluminense University, Antônio Pedro University Hospital, 24033-900, Niterói, Rio de Janeiro, Brazil
- Resource Type
- Journal article
- Publication Details
- Journal of the neurological sciences, Vol.372, pp.73-74
- DOI
- 10.1016/j.jns.2016.11.030
- PMID
- 28017252
- ISSN
- 0022-510X
- eISSN
- 1878-5883
- Language
- English
- Date published
- 01/15/2017
- Academic Unit
- Stead Family Department of Pediatrics; Developmental and Behavioral Pediatrics
- Record Identifier
- 9984093363502771
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