Journal article
Microfluidic Isolation and Enrichment of Nanoparticles
ACS nano, Vol.14(12), pp.16220-16240
12/22/2020
DOI: 10.1021/acsnano.0c06336
PMID: 33252215
Abstract
Over the past decades, nanoparticles have increased in implementation to a variety of applications ranging from high-efficiency electronics to targeted drug delivery. Recently, microfluidic techniques have become an important tool to isolate and enrich populations of nanoparticles with uniform properties ( e.g. , size, shape, charge) due to their precision, versatility, and scalability. However, due to the large number of microfluidic techniques available, it can be challenging to identify the most suitable approach for isolating or enriching a nanoparticle of interest. In this review article, we survey microfluidic methods for nanoparticle isolation and enrichment based on their underlying mechanisms, including acoustofluidics, dielectrophoresis, filtration, deterministic lateral displacement, inertial microfluidics, optofluidics, electrophoresis, and affinity-based methods. We discuss the principles, applications, advantages, and limitations of each method. We also provide comparisons with bulk methods, perspectives for future developments and commercialization, and next-generation applications in chemistry, biology, and medicine.
Details
- Title: Subtitle
- Microfluidic Isolation and Enrichment of Nanoparticles
- Creators
- Yuliang Xie - University of IowaJoseph Rufo - Duke UniversityRuoyu Zhong - Duke UniversityJoseph Rich - Duke UniversityPeng Li - West Virginia UniversityKam W Leong - Columbia UniversityTony Jun Huang - Duke University
- Resource Type
- Journal article
- Publication Details
- ACS nano, Vol.14(12), pp.16220-16240
- DOI
- 10.1021/acsnano.0c06336
- PMID
- 33252215
- NLM abbreviation
- ACS Nano
- ISSN
- 1936-0851
- eISSN
- 1936-086X
- Publisher
- American Chemical Society
- Grant note
- DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UG3TR002978; DOI: 10.13039/100000054, name: National Cancer Institute, award: R33CA223908; DOI: 10.13039/100000182, name: Medical Research and Materiel Command, award: W81XWH-18-1-0242; DOI: 10.13039/100000071, name: National Institute of Child Health and Human Development, award: R01HD086325; DOI: 10.13039/100000148, name: Division of Electrical, Communications and Cyber Systems, award: ECCS-1807601; DOI: 10.13039/100000057, name: National Institute of General Medical Sciences, award: R01GM127714, R01GM132603, R01GM135486
- Language
- English
- Date published
- 12/22/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984196984602771
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