Microparticles prepared from sulfenamide-based polymers

Sheetal R D'Mello; Jun Yoo; Ned B Bowden; Aliasger K Salem

doi:10.3109/02652048.2013.814728

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Microparticles prepared from sulfenamide-based polymers

Journal article

Peer reviewed

Microparticles prepared from sulfenamide-based polymers

Sheetal R D'Mello, Jun Yoo, Ned B Bowden and Aliasger K Salem

Journal of Microencapsulation, Vol.31(2), pp.137-146

03/01/2014

DOI: 10.3109/02652048.2013.814728

PMCID: PMC4295722

PMID: 23862723

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http://doi.org/10.3109/02652048.2013.814728View

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Abstract

Polysulfenamides (PSN), with a SN linkage (RSNR 2 ) along the polymer backbone, are a new class of biodegradable and biocompatible polymers. These polymers were unknown prior to 2012 when their synthesis and medicinally relevant properties were reported. The aim of this study was to develop microparticles as a controlled drug delivery system using polysulfenamide as the matrix material. The microparticles were prepared by a water-in-oil-in-water double-emulsion solvent-evaporation method. For producing drug-loaded particles, FITC-dextran was used as a model hydrophilic compound. At the optimal formulation conditions, the external morphology of the PSN microparticles was examined by scanning electron microscopy to show the formation of smooth-surfaced spherical particles with low polydispersity. The microparticles had a net negative surface charge (-23 mV) as analyzed by the zetasizer. The drug encapsulation efficiency of the particles and the drug loading were found to be dependent on the drug molecular weight, amount of FITC-dextran used in fabricating FITC-dextran-loaded microparticles, concentration of PSN and surfactant, and volume of the internal and external water phases. FITC-dextran was found to be distributed throughout the PSN microparticles and was released in an initial burst followed by more continuous release over time. Confocal laser scanning microscopy was used to qualitatively observe the cellular uptake of PSN microparticles and indicated localization of the particles in both the cytoplasm and the nucleus.

particle size

biodegradable

controlled release

polysulfenamide

Biocompatible

microparticles

cellular uptake

Details

Title: Subtitle: Microparticles prepared from sulfenamide-based polymers
Creators: Sheetal R D'Mello - Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, University of Iowa
Jun Yoo - Department of Chemistry, College of Liberal Arts and Sciences, University of Iowa
Ned B Bowden - Department of Chemistry, College of Liberal Arts and Sciences, University of Iowa
Aliasger K Salem - Department of Pharmaceutical Sciences & Experimental Therapeutics, College of Pharmacy, University of Iowa
Resource Type: Journal article
Publication Details: Journal of Microencapsulation, Vol.31(2), pp.137-146
DOI: 10.3109/02652048.2013.814728
PMID: 23862723
PMCID: PMC4295722
NLM abbreviation: J Microencapsul
ISSN: 0265-2048
eISSN: 1464-5246
Publisher: Taylor & Francis
Language: English
Date published: 03/01/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Chemistry; Dental Research; Chemical and Biochemical Engineering
Record Identifier: 9983985855702771

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