Journal article
Micropore closure kinetics are delayed following microneedle insertion in elderly subjects
Journal of controlled release, Vol.225, pp.294-300
03/10/2016
DOI: 10.1016/j.jconrel.2016.01.051
PMID: 26829102
Abstract
Transdermal delivery is an advantageous method of drug administration, particularly for an elderly population. Microneedles (MNs) allow transdermal delivery of otherwise skin-impermeable drugs by creating transient micropores that bypass the barrier function of the skin. The response of aging skin to MNs has not been explored, and we report for the first time that micropore closure is delayed in elderly subjects in a manner that is dependent upon MN length, number, and occlusion of the micropores. Twelve control subjects (25.6±2.8years) and 16 elderly subjects (77.3±6.8years) completed the study. Subjects were treated with MNs of 500μm or 750μm length, in arrays containing 10 or 50 MNs. Impedance measurements made at baseline, post-MN insertion, and at predetermined time points demonstrated that restoration of the skin barrier is significantly slower in elderly subjects under both occluded and non-occluded conditions. This was confirmed via calculation of the total permeable area created by the micropores (which would approximate the area available for drug delivery), as well as calculation of the micropore half-life. This pilot study demonstrates that longer timeframes are required to restore the barrier function of aged skin following MN insertion, suggesting that drug delivery windows could be longer following one treatment with a MN array.
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Details
- Title: Subtitle
- Micropore closure kinetics are delayed following microneedle insertion in elderly subjects
- Creators
- Megan N Kelchen - University of Iowa College of Pharmacy, Department of Pharmaceutical Sciences and Experimental Therapeutics, 115 S. Grand Ave, Iowa City, IA 52242, USAKyle J Siefers - University of Iowa College of Pharmacy, Department of Pharmaceutical Sciences and Experimental Therapeutics, 115 S. Grand Ave, Iowa City, IA 52242, USACourtney C Converse - University of Iowa College of Pharmacy, Department of Pharmaceutical Sciences and Experimental Therapeutics, 115 S. Grand Ave, Iowa City, IA 52242, USAMatthew J Farley - University of Iowa College of Pharmacy, Department of Pharmaceutical Sciences and Experimental Therapeutics, 115 S. Grand Ave, Iowa City, IA 52242, USAGrant O Holdren - University of Iowa College of Pharmacy, Department of Pharmaceutical Sciences and Experimental Therapeutics, 115 S. Grand Ave, Iowa City, IA 52242, USANicole K Brogden - University of Iowa College of Pharmacy, Department of Pharmaceutical Sciences and Experimental Therapeutics, 115 S. Grand Ave, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Journal of controlled release, Vol.225, pp.294-300
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jconrel.2016.01.051
- PMID
- 26829102
- ISSN
- 0168-3659
- eISSN
- 1873-4995
- Language
- English
- Date published
- 03/10/2016
- Academic Unit
- Dermatology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984025362402771
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