Micropore closure time is longer following microneedle application to skin of color

Abayomi T. Ogunjimi; Jamie Carr; Christine Lawson; Nkanyezi Ferguson; Nicole K. Brogden

doi:10.1038/s41598-020-75246-8

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Micropore closure time is longer following microneedle application to skin of color

Journal article

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Micropore closure time is longer following microneedle application to skin of color

Abayomi T. Ogunjimi, Jamie Carr, Christine Lawson, Nkanyezi Ferguson and Nicole K. Brogden

Scientific reports, Vol.10(1), pp.18963-18963

11/03/2020

DOI: 10.1038/s41598-020-75246-8

PMCID: PMC7609754

PMID: 33144596

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Abstract

Microneedles (MNs) allow transdermal delivery of skin-impermeable drugs by creating transient epidermal micropores, and micropore lifetime directly affects drug diffusion timeframes. Healthy subjects (n = 111) completed the study, self-identifying as Asian (n = 32), Bi-/multi-racial (n = 10), Black (n = 22), White (n = 23), Latino (n = 23), and Native American/Hawaiian (n = 1). L* was measured with tristimulus colorimetry to objectively describe skin lightness/darkness. MNs were applied to the upper arm; impedance and transepidermal water loss (TEWL) were measured at baseline and post-MN to confirm micropore formation. Impedance was repeated for 4 days to determine micropore lifetime. Post-MN changes in TEWL and impedance were significant in all groups (p < 0.05), confirming micropore formation regardless of skin type. Micropore lifetime was significantly longer in Blacks (66.5 +/- 19.5 h) versus Asians (44.1 +/- 14.0 h), Bi-/multi-racial (48.0 +/- 16.0 h), and Whites (50.2 +/- 2.6 h). Latinos (61.1 +/- 16.1 h) had significantly longer micropore closure time versus Asians (44.1 +/- 14.0 h). When categorizing data according to L*, micropore lifetime was significantly longer in darker skin. We report for the first time that micropore lifetime differences are present in human subjects of different ethnic/racial backgrounds, with longer micropore lifetime in skin of color. These results also suggest that objectively measured skin color is a better predictor of micropore lifetime than self-identified race/ethnicity.

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Details

Title: Subtitle: Micropore closure time is longer following microneedle application to skin of color
Creators: Abayomi T. Ogunjimi - University of Iowa
Jamie Carr - University of Iowa
Christine Lawson - University of Iowa
Nkanyezi Ferguson - Roy J. and Lucille A. Carver College of Medicine
Nicole K. Brogden - University of Iowa
Resource Type: Journal article
Publication Details: Scientific reports, Vol.10(1), pp.18963-18963
DOI: 10.1038/s41598-020-75246-8
PMID: 33144596
PMCID: PMC7609754
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: Springer Nature
Number of pages: 14
Grant note: R35GM124551; UL1TR002537 / National Center For Advancing Translational Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
Language: English
Date published: 11/03/2020
Academic Unit: Dermatology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984296304602771

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