Journal article
Microsomal Flavin‐Containing Monooxygenase Activity in Rat Corpus Striatum
Journal of neurochemistry, Vol.42(5), pp.1350-1353
05/1984
DOI: 10.1111/j.1471-4159.1984.tb02794.x
PMID: 6707640
Abstract
: Microsomal fractions isolated from rat corpus striatum catalyze the oxidation of thiobenzamide to the sulfoxide. The rate of thiobenzamide sulfoxidation is 6.9 ± 4.8 nmol (min)−1 (mg microsomal protein)−1. The reaction is inhibited by an excess of sulfur‐and nitrogen‐containing substrates for the microsomal flavin‐containing monooxygenase. These inhibitors of thiobenzamide sulfoxidation include methimazole, cysteamine, and trimethylamine. Enzyme activity is also destroyed by treatment of the microsomal preparation at 60± for 1 min. In parallel experiments, rat liver microsomes exhibit similar inhibition characteristics. The data indicate the presence in corpus striatum of a microsomal monooxygenase with catalytic properties of the hepatic microsomal flavin‐containing monooxygenase.
Details
- Title: Subtitle
- Microsomal Flavin‐Containing Monooxygenase Activity in Rat Corpus Striatum
- Creators
- Michael W. Duffel - University of IowaStephen G. Gillespie - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neurochemistry, Vol.42(5), pp.1350-1353
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1471-4159.1984.tb02794.x
- PMID
- 6707640
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- Number of pages
- 4
- Language
- English
- Date published
- 05/1984
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984303161702771
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