Journal article
Microtubules, Membranes, and Movement: New Roles for Stathmin‐2 in Axon Integrity
Journal of neuroscience research, Vol.102(9), e25382
09/2024
DOI: 10.1002/jnr.25382
PMCID: PMC11407747
PMID: 39253877
Appears in UI Libraries Support Open Access
Abstract
ABSTRACT Neurons establish functional connections responsible for how we perceive and react to the world around us. Communication from a neuron to its target cell occurs through a long projection called an axon. Axon distances can exceed 1 m in length in humans and require a dynamic microtubule cytoskeleton for growth during development and maintenance in adulthood. Stathmins are microtubule‐associated proteins that function as relays between kinase signaling and microtubule polymerization. In this review, we describe the prolific role of Stathmins in microtubule homeostasis with an emphasis on emerging roles for Stathmin‐2 (Stmn2) in axon integrity and neurodegeneration. Stmn2 levels are altered in Amyotrophic Lateral Sclerosis and loss of Stmn2 provokes motor and sensory neuropathies. There is growing potential for employing Stmn2 as a disease biomarker or even a therapeutic target. Meeting this potential requires a mechanistic understanding of emerging complexity in Stmn2 function. In particular, Stmn2 palmitoylation has a surprising contribution to axon maintenance through undefined mechanisms linking membrane association, tubulin interaction, and axon transport. Exploring these connections will reveal new insight on neuronal cell biology and novel opportunities for disease intervention.
Details
- Title: Subtitle
- Microtubules, Membranes, and Movement: New Roles for Stathmin‐2 in Axon Integrity
- Creators
- Emma J. C. Thornburg-Suresh - University of Iowa, BiologyDaniel W. Summers - Department of Biology University of Iowa Iowa City Iowa USA, Iowa Neuroscience Institute University of Iowa Iowa City Iowa USA
- Resource Type
- Journal article
- Publication Details
- Journal of neuroscience research, Vol.102(9), e25382
- Publisher
- Wiley
- DOI
- 10.1002/jnr.25382
- PMID
- 39253877
- PMCID
- PMC11407747
- ISSN
- 0360-4012
- eISSN
- 1097-4547
- Grant note
We appreciate thoughtful comments provided by members of the Summers Lab during preparation of this manuscript. This work was supported by a grant to D.W.S. from the National Institutes of Health (R01NS126191).
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984702957802771
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